Evidence map›Paper›PMID 38795603›Full record

ArticleDNA repair2024

Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations.

Jamie T Zuckerman, Asia Sage Jackson, Irina G Minko, Melis Kant, Pawel Jaruga, Michael P Stone, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Aflatoxin BEnvironmental and molecular mutagenesis · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jamie T ZuckermanOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States.
Asia Sage JacksonOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States; Department of Math & Sciences, Corban University, Salem, OR 97317, United States.
Irina G MinkoOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States.
Melis KantBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Pawel JarugaBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Michael P StoneDepartment of Chemistry, Vanderbilt University, Nashville, TN 37240, United States.
Miral DizdarogluBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Amanda K McCulloughOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States.
R Stephen LloydOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States. Electronic address: lloydst@ohsu.edu.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
DNA Adduct-Induced MutagenesisR01CA055678 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1992 to 2016
$4.0M
DNA Adduct-Induced MutagenesisR01ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2018 to 2022
$2.6M
Role of Base Excision Repair in Limiting Hepatocellular Carcinomas -Administrative SupplementR01ES031086 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LLOYD, R. STEPHEN · 2020 to 2024
$2.0M
DNA Adduct-Induced MutagenesisR56ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2024 to 2024
$250k
NCI NIH HHS P01 CA160032NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA055678NIEHS NIH HHS R01 ES029357NIEHS NIH HHS R01 ES031086NIEHS NIH HHS R56 ES029357
6 · The paper itself

Abstract

The base excision repair (BER) pathway is a precise and versatile mechanism of DNA repair that is initiated by DNA glycosylases. Endonuclease VIII-like 1 (NEIL1) is a bifunctional glycosylase/abasic site (AP) lyase that excises a damaged base and subsequently cleaves the phosphodiester backbone. NEIL1 is able to recognize and hydrolyze a broad range of oxidatively-induced base lesions and substituted ring-fragmented guanines, including aflatoxin-induced 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B

Indexed as

DNA GlycosylasesDNA RepairPolymorphism, Single NucleotideAflatoxin B1Carcinoma, HepatocellularDNA DamageHumansLiver NeoplasmsSubstrate SpecificityAflatoxin B1DNA GlycosylasesNEIL1 protein, humanAflatoxinBase excision repairHepatocellular carcinomaOxidatively-induced DNA damage

Identifiers

PMID38795603
PMCPMC11218669

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.