Evidence map›Paper›PMID 38795388›Full record

ArticleAging2024

DKK2 promotes the progression of oral squamous cell carcinoma through the PI3K/AKT signaling pathway.

Wenbo Guo, Yun Qu, Yang Yu, Xueming Li, Zhuang Liang, Zhaoqi Wang, Tenglong Hu, Shan Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenbo GuoDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin 150001, Heilongjiang, China.
Yun QuDepartment of Orthodontics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.
Yang YuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin 150001, Heilongjiang, China.
Xueming LiDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin 150001, Heilongjiang, China.
Zhuang LiangDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin 150001, Heilongjiang, China.
Zhaoqi WangDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin 150001, Heilongjiang, China.
Tenglong HuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin 150001, Heilongjiang, China.
Shan ZhouDepartment of Orthodontics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the impact of Dickkopf 2 (DKK2) on the progression of oral squamous cell carcinoma (OSCC) and explore its role in the PI3K/AKT signaling transduction pathway. MATERIALS AND

methodsThe study initially examined the expression of the DKK2 gene in OSCC tissues and normal tissues. Simultaneously, the expression of DKK2 in HOK cells and OSCC cells was verified, and changes in DKK2 expression under hypoxic conditions were detected. DKK2 overexpression and knockdown were performed in SCC-15 and CAL-27 cells. Subsequently, the effects of DKK2 on the proliferation, migration and invasion of OSCC were detected. Western blotting was employed to detect the expression of key proteins in the DKK2/PI3K/AKT signaling axis before and after transfection, and further explore the relevant molecular mechanisms.

resultsCompared to normal tissues, DKK2 expression was elevated in OSCC tissues. The expression of DKK2 in the SCC-15 and CAL-27 cell lines was higher than that in HOK cells, and hypoxic conditions could promote DKK2 expression. DKK2 overexpression promoted cell proliferation, migration, and invasion, while DKK2 knockdown inhibited these processes. DKK2 overexpression activated the PI3K/AKT pathway, while DKK2 knockdown suppressed this pathway.

conclusionThis study suggests that hypoxic conditions enhance the expression of DKK2 in OSCC. DKK2 regulates the proliferation, migration, and invasion of OSCC through the PI3K/AKT signaling pathway.

Indexed as

Carcinoma, Squamous CellCell MovementCell ProliferationIntercellular Signaling Peptides and ProteinsMouth NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionCell Line, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessDKK2 protein, humanIntercellular Signaling Peptides and ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktDKK2hypoxiaoral squamous cell carcinomaPI3K/AKT

Identifiers

PMID38795388
PMCPMC11164507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.