Evidence map›Paper›PMID 38795221›Full record

ReviewFamilial cancer2024

Review of the cost-effectiveness of surveillance for hereditary pancreatic cancer.

Louise Wang, Rachel Levinson, Catherine Mezzacappa, Bryson W Katona

Abstract readReview
In one paragraph

Review in Familial cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
  6. Challenges of early detection of pancreatic cancer.The Journal of clinical investigation · 2025
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Louise WangSection of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA.
Rachel LevinsonSection of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA.
Catherine MezzacappaSection of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA.
Bryson W KatonaDivision of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd. 751 South Pavilion, Philadelphia, PA, 19104, USA. bryson.katona@pennmedicine.upenn.edu.

Funding

Training Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4M
Short Term Research Training: Students in Health Professional SchoolsT35DK104689 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY, Sarwat I Chaudhry · 2015 to 2026
$2.6M
Pancreatic Cancer Risk Prediction: Integrating Individual-Level Clinical and Genetic DataIK2BX005891 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI Louise L Wang · 2023 to 2026
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BLRD VA IK2 BX005891NIDDK NIH HHS T32 DK007356NIDDK NIH HHS T32DK007356NIDDK NIH HHS T35 DK104689U.S. Department of Veterans Affairs 1IK2BX005891
6 · The paper itself

Abstract

Individuals with hereditary pancreatic cancer risk include high risk individuals (HRIs) with germline genetic susceptibility to pancreatic cancer (PC) and/or a strong family history of PC. Previously, studies have shown that PC surveillance in HRIs can downstage PC diagnosis and extend survival leading to pancreatic surveillance being recommended for certain HRIs. However, the optimal surveillance strategy remains uncertain, including which modalities should be used for surveillance, how frequently should surveillance be performed, and which sub-groups of HRIs should undergo surveillance. Additionally, in the ideal world PC surveillance should also be cost-effective. Cost-effectiveness analysis is a valuable tool that can consider the costs, potential health benefits, and risks among various PC surveillance strategies. In this review, we summarize the cost-effectiveness of various PC surveillance strategies for HRIs for hereditary pancreatic cancer and provide potential avenues for future work in this field. Additionally, we include cost-effectiveness studies among individuals with new-onset diabetes (NoD), a high-risk group for sporadic PC, as a comparison.

Indexed as

Cost-Benefit AnalysisGenetic Predisposition to DiseasePancreatic NeoplasmsCarcinomaEarly Detection of CancerGenetic TestingHumansCost-effectivenessEndoscopic ultrasoundGermline genetic riskHereditary pancreatic cancerMRINew-onset diabetesPancreatic surveillance

Identifiers

PMID38795221
PMCPMC11255025

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.