ArticleAmerican journal of epidemiology2024
Childhood adversity and time to pregnancy in a preconception cohort.
Article in American journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Discrimination and risk of spontaneous abortion in a preconception cohort study.Social science & medicine (1982) · 2026Article
- Childhood adversity and spontaneous abortion in a North American preconception cohort study.American journal of epidemiology · 2026Article
- Fecundability in Association With Everyday and Lifetime Discrimination.JAMA network open · 2025Article
- Experiences of discrimination across the life course among pregnancy planners in the United States and Canada.SSM - population health · 2025Article
- Association of Early-life Trauma With Gestational Diabetes and Hypertensive Disorders of Pregnancy.Epidemiology (Cambridge, Mass.) · 2025Article
- Are the Previously Reported Risk Factors for Endometriosis Actually Associated With Pain and Infertility Rather Than Endometriosis Itself?Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We examined the association between childhood adversity and fecundability (the per-cycle probability of conception), and the extent to which childhood social support modified this association. We used data from 6318 female participants aged 21-45 years in Pregnancy Study Online (PRESTO), a North American prospective preconception cohort study (2013-2022). Participants completed a baseline questionnaire, bimonthly follow-up questionnaires (until pregnancy or a censoring event), and a supplemental questionnaire on experiences across the life course including adverse childhood experiences (ACEs) and social support (using the modified Berkman-Syme Social Network Index [SNI]). We used proportional probabilities regression models to compute fecundability ratios (FRs) and 95% CIs, adjusting for potential confounders and precision variables. Adjusted FRs for ACE scores 1-3 and ≥4 vs 0 were 0.91 (95% CI, 0.85-0.97) and 0.84 (95% CI, 0.77-0.91), respectively. The FRs for ACE scores ≥4 vs 0 were 0.86 (95% CI, 0.78-0.94) among participants reporting high childhood social support (SNI ≥4) and 0.78 (95% CI, 0.56-1.07) among participants reporting low childhood social support (SNI <4). Our findings confirm results from 2 previous studies and indicate that high childhood social support slightly buffered the effects of childhood adversity on fecundability.
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Registered trials
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