Evidence map›Paper›PMID 38794765›Full record

ArticleNutrients2024

Indulging Curiosity: Preliminary Evidence of an Anxiolytic-like Effect of Castor Oil and Ricinoleic Acid.

Khalin E Nisbett, Leandro F Vendruscolo, George F Koob

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antioxidants (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Khalin E NisbettGraduate Program in Neuroscience, Graduate College, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0009-0009-7978-8147
Leandro F VendruscoloStress and Addiction Neuroscience Unit, Integrative Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD 21224, USA.ORCID 0000-0002-8829-8627
George F KoobNeurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

Funding

Neurobiology of AddictionZIADA000602 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI KOOB, GEORGE · 2019 to 2025
$16.3M
Stress and Addiction Neuroscience UnitZIADA000644 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI VENDRUSCOLO, LEANDRO · 2023 to 2025
$4.1M
NIDA, NIAAA 000-IRP
6 · The paper itself

Abstract

In the process of validating the elevated zero maze, a common test of anxiety-like behavior, in our laboratory, we demonstrated an anxiolytic-like effect of castor oil and its primary component, ricinoleic acid. We tested the effects of vehicle and chlordiazepoxide in male mice in the elevated zero maze following a 30-min pretreatment time. Chlordiazepoxide is a United States Food and Drug Administration-approved drug that was previously shown to exert anxiolytic-like effects in both the elevated zero maze and elevated plus maze. Chlordiazepoxide was administered at doses of 5 or 10 mg/kg. We used 5% polyoxyl 35 castor oil (Kolliphor

Indexed as

Anti-Anxiety AgentsAnxietyCastor OilRicinoleic AcidsAnimalsBehavior, AnimalChlordiazepoxideExploratory BehaviorMaleMaze LearningMiceAnti-Anxiety AgentsCastor OilChlordiazepoxidericinoleic acidRicinoleic Acidsanxietycastor oilkolliphorricinoleic acid

Identifiers

PMID38794765
PMCPMC11124509

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.