Evidence map›Paper›PMID 38794702›Full record

ArticleNutrients2024

GHSR Deletion in β-Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced β-Cell Injury in Aging.

Hye Won Han, Geetali Pradhan, Daniel Villarreal, Da Mi Kim, Abhishek Jain, Akhilesh Gaharwar, Yanan Tian, Shaodong Guo, Yuxiang Sun

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hye Won HanDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9839-0996
Geetali PradhanUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Daniel VillarrealDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Da Mi KimDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Abhishek JainDepartment of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-2235-5139
Akhilesh GaharwarDepartment of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843, USA.
Yanan TianDepartment of Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Shaodong GuoDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0001-5126-731X
Yuxiang SunDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Sakhila Banu · 2019 to 2026
$13.0M
Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered vein-chipR01HL157790 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CONNOR, JOHN H, COOKE, JOHN P · 2021 to 2024
$2.8M
Nutrient-sensing GHS-R in macrophage reprogramming and inflamm-agingR01AG064869 · NIA · TEXAS A&M AGRILIFE RESEARCH · PI SUN, YUXIANG · 2019 to 2023
$2.1M
Hepatic TGFbeta1 in Control of Type 2 Diabetes and NASH via FoxO1 SignalingR01DK124588 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI GUO, SHAODONG · 2022 to 2025
$2.0M
The role of GHS-R in macrophage reprogramming during meta-inflammationR01DK118334 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI SUN, YUXIANG · 2019 to 2022
$1.2M
Multistate 1022378NHLBI NIH HHS R01 HL157790NIA NIH HHS R01 AG064869NIDDK NIH HHS R01 DK118334NIDDK NIH HHS R01 DK124588NIEHS NIH HHS P30 ES029067NIH HHS 1R01AG064869NIH HHS 1R01DK118334NIH HHS 1R01DK124588NIH HHS 1R01HL157790NSF CAREER Award number 1944322USDA/NIFA Hatch 7001445
6 · The paper itself

Abstract

Insulin secretion from pancreatic β cells is a key pillar of glucose homeostasis, which is impaired under obesity and aging. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient-sensing hormone ghrelin. Previously, we showed that β-cell GHSR regulated glucose-stimulated insulin secretion (GSIS) in young mice. In the current study, we further investigated the effects of GHSR on insulin secretion in male mice under diet-induced obesity (DIO) and streptozotocin (STZ)-induced β-cell injury in aging. β-cell-specific-

Indexed as

AgingInsulin-Secreting CellsObesityReceptors, GhrelinAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalHyperglycemiaInsulinInsulin ResistanceInsulin SecretionMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionBlood GlucoseInsulinReceptors, GhrelinStreptozocinagingghrelingrowth hormone secretagogue receptor (GHSR)pancreatic isletsstreptozotocin (STZ)β-cell

Identifiers

PMID38794702
PMCPMC11123813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.