Evidence map›Paper›PMID 38794641›Full record

ArticleNutrients2024

Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes.

Gabriella H Kalantar, Shubh Saraswat, Sara SantaCruz-Calvo, Fatemeh Gholamrezaeinejad, Aida Javidan, Madhur Agrawal, Rui Liu, Philip A Kern, Xiaohua Douglas Zhang, Barbara S Nikolajczyk

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gabriella H KalantarDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-1573-3787
Shubh SaraswatDepartment of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.ORCID 0009-0009-2359-1484
Sara SantaCruz-CalvoDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
Fatemeh GholamrezaeinejadDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
Aida JavidanDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
Madhur AgrawalDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
Rui LiuDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-0619-4902
Philip A KernDepartment of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-4761-7417
Xiaohua Douglas ZhangDepartment of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-2486-7931
Barbara S NikolajczykDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0001-5647-5740

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Sustained eIF5A hypusination at the core of brain metabolic dysfunction in TDP-43 proteinopathiesP20GM148326 · NIGMS · UNIVERSITY OF KENTUCKY · PI Patrick G Sullivan · 2023 to 2026
$10.6M
NRSA Training CoreTL1TR001997 · NCATS · UNIVERSITY OF KENTUCKY · PI PENDERGAST, JULIE S, STOOPS, WILLIAM WALTON · 2016 to 2025
$4.2M
Inflammation in human obesity and type 2 diabetesR01DK108056 · NIDDK · UNIVERSITY OF KENTUCKY · PI LAUFFENBURGER, DOUGLAS A, NIKOLAJCZYK, BARBARA · 2016 to 2019
$2.6M
TRAINING PROGRAM IN OXIDATIVE STRESS AND NUTRITIONT32DK007778 · NIDDK · UNIVERSITY OF KENTUCKY · PI WEBB, NANCY R · 2000 to 2019
$2.5M
Restoration of Impaired Awareness of Hypoglycemia U01 Consortium: University of KentuckyU01DK135111 · NIDDK · UNIVERSITY OF KENTUCKY · PI SIMON J FISHER · 2022 to 2026
$2.3M
The impact of insulin sensitivity on the potential of metformin to delay age-related inflammationR01AG079525 · NIA · UNIVERSITY OF KENTUCKY · PI NIKOLAJCZYK, BARBARA · 2022 to 2025
$2.3M
The Biological Mechanisms of Metformin Effects on Aging-Associated InflammationR56AG069685 · NIA · UNIVERSITY OF KENTUCKY · PI NIKOLAJCZYK, BARBARA · 2020 to 2020
$380k
NCATS NIH HHS TL1 TR001997NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NCI NIH HHS P30CA177558NIA NIH HHS R01 AG079525NIA NIH HHS R56 AG069685NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK108056NIDDK NIH HHS T32 DK007778NIDDK NIH HHS U01 DK135111NIGMS NIH HHS P20 GM148326NIH HHS R01DK108056NIH HHS T32DK007778NIH HHS TL1UL1TR001998NIH HHS UL1TR001998University of Kentucky College of Medicine
6 · The paper itself

Abstract

Cytokines produced by peripheral T-helper 1/17 cells disproportionately contribute to the inflammation (i.e., metaflammation) that fuels type 2 diabetes (T2D) pathogenesis. Shifts in the nutrient milieu could influence inflammation through changes in T-cell metabolism. We aimed to determine whether changes in glucose utilization alter cytokine profiles in T2D. Peripheral blood mononuclear cells (PBMCs), CD4

Indexed as

CD4-Positive T-LymphocytesCytokinesDiabetes Mellitus, Type 2FastingInflammationLeukocytes, MononuclearAdultAgedBlood GlucoseFemaleGlucoseHumansMaleMiddle AgedBlood GlucoseCytokinesGlucosecytokinesextracellular fluxglycemic controlHba1Cobesitypartial least squares discriminant analysissystemic inflammation

Identifiers

PMID38794641
PMCPMC11124302

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.