Evidence map›Paper›PMID 38794609›Full record

ArticlePolymers2024

Polydimethylsiloxane Surface Modification of Microfluidic Devices for Blood Plasma Separation.

Margarida Gonçalves, Inês Maia Gonçalves, Joel Borges, Vera Faustino, Delfim Soares, Filipe Vaz, Graça Minas, Rui Lima, Diana Pinho

Abstract read
In one paragraph

Article in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margarida GonçalvesMicroelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0009-0001-7625-167X
Inês Maia GonçalvesMEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0001-7986-8934
Joel BorgesPhysics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0001-7421-6902
Vera FaustinoMicroelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0001-9041-2188
Delfim SoaresMicroelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0003-1884-2380
Filipe VazPhysics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0001-5506-996X
Graça MinasMicroelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0003-2460-0556
Rui LimaMEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0003-3428-637X
Diana PinhoMicroelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal.ORCID 0000-0002-3884-6496

Funding

This work was supported by the projects, 2022.02085.PTDC (https://doi.org/10.54499/2022.02085.PTDC), 2022.06207.PTDC (https://doi.org/10.54499/2022.06207.PTDC), PTDC/EEI-EEE/2846/2021 (https://doi.org/10.54499/PTDC/EEI-EEE/2846/2021) and through national This work was supported by the projects, 2022.02085.PTDC (https://doi.org/10.54499/2022.02085.PTDC), 2022.06207.PTDC (https://doi.org/10.54499/2022.06207.PTDC), PTDC/EEI-EEE/2846/2021 (https://doi.org/10.54499/PTDC/EEI-EEE/2846/2021) and through national
6 · The paper itself

Abstract

Over the last decade, researchers have developed a variety of new analytical and clinical diagnostic devices. These devices are predominantly based on microfluidic technologies, where biological samples can be processed and manipulated for the collection and detection of important biomolecules. Polydimethylsiloxane (PDMS) is the most commonly used material in the fabrication of these microfluidic devices. However, it has a hydrophobic nature (contact angle with water of 110°), leading to poor wetting behavior and issues related to the mixing of fluids, difficulties in obtaining uniform coatings, and reduced efficiency in processes such as plasma separation and molecule detection (protein adsorption). This work aimed to consider the fabrication aspects of PDMS microfluidic devices for biological applications, such as surface modification methods. Therefore, we studied and characterized two methods for obtaining hydrophilic PDMS surfaces: surface modification by bulk mixture and the surface immersion method. To modify the PDMS surface properties, three different surfactants were used in both methods (Pluronic

Indexed as

blood flow studiescapillary studiesmicrofluidic devicesPDMSsurface modification

Identifiers

PMID38794609
PMCPMC11125454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.