Evidence map›Paper›PMID 38794344›Full record

ArticlePharmaceutics2024

Investigation of Hydrocolloid Plant Polysaccharides as Potential Candidates to Mimic the Functions of MUC5B in Saliva.

Christina Winter, Carolin Tetyczka, Duy Toan Pham, Dagmar Kolb, Gerd Leitinger, Sandra Schönfelder, Olaf Kunert, Tanja Gerlza, Andreas Kungl, Franz Bucar and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina WinterInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Universitätsplatz 1, 8010 Graz, Austria.
Carolin TetyczkaInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Universitätsplatz 1, 8010 Graz, Austria.
Duy Toan PhamDepartment of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam.ORCID 0000-0002-8693-3367
Dagmar KolbCore Facility Ultrastructure Analysis, Center for Medical Research, Medical University of Graz, Neue Stiftingtalstrasse 6/VI, 8010 Graz, Austria.
Gerd LeitingerDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstrasse 6/V, 8010 Graz, Austria.ORCID 0000-0002-5281-9830
Sandra SchönfelderInstitute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Beethovenstraße 8, 8010 Graz, Austria.
Olaf KunertInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, 8010 Graz, Austria.ORCID 0000-0002-7091-5973
Tanja GerlzaInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, 8010 Graz, Austria.ORCID 0000-0003-4947-9721
Andreas KunglInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, 8010 Graz, Austria.ORCID 0000-0003-3362-797X
Franz BucarInstitute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Beethovenstraße 8, 8010 Graz, Austria.ORCID 0000-0002-7417-616X
Eva RobleggInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Universitätsplatz 1, 8010 Graz, Austria.ORCID 0000-0002-5553-5147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The successful substitution of complex physiological fluids, such as human saliva, remains a major challenge in drug development. Although there are a large number of saliva substitutes on the market, their efficacy is often inadequate due to short residence time in the mouth, unpleasant mouthfeel, or insufficient protection of the teeth. Therefore, systems need to be identified that mimic the functions of saliva, in particular the salivary mucin MUC5B and the unique physiological properties of saliva. To this end, plant extracts known to contain hydrocolloid polysaccharides and to have mucus-forming properties were studied to evaluate their suitability as saliva substitutes. The aqueous plant extracts of

Indexed as

in vitro adhesionMUC5Bnatural compoundsplant extractssalivasaliva substitutionTR146 cellsUWSxerostomia

Identifiers

PMID38794344
PMCPMC11124828

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.