Evidence map›Paper›PMID 38794257›Full record

ArticlePharmaceutics2024

Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment.

Ming-Lu Lin, Siao-Yun Wu, Jyh-Ping Chen, Yi-Ching Lu, Shih-Ming Jung, Shiaw-Pyng Wey, Tony Wu, Yunn-Hwa Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ming-Lu LinDepartment of Physiology & Pharmacology, College of Medicine, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.
Siao-Yun WuDepartment of Physiology & Pharmacology, College of Medicine, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.
Jyh-Ping ChenDepartment of Chemical and Materials Engineering, College of Engineering, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.ORCID 0000-0001-6527-4801
Yi-Ching LuDepartment of Physiology & Pharmacology, College of Medicine, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.
Shih-Ming JungDepartment of Pathology, Chang Gung Memorial Hospital, Guishan, Taoyuan 33305, Taiwan.
Shiaw-Pyng WeyDepartment of Medical Imaging and Radiological Sciences, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.ORCID 0000-0002-7222-2601
Tony WuDepartment of Neurology, Chang Gung Memorial Hospital, Guishan, Taoyuan 33305, Taiwan.
Yunn-Hwa MaDepartment of Physiology & Pharmacology, College of Medicine, Chang Gung University, Guishan, Taoyuan 33302, Taiwan.ORCID 0000-0002-0481-1180

Funding

Chang Gung Memorial Hospital BMRP466Chang Gung Memorial Hospital CMRPD1H0363National Science and Technology Countil, Taiwan MOST110-2124-M-182-001-National Science and Technology Countil, Taiwan MOST 111-2811-M-182-002
6 · The paper itself

Abstract

Plasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circulation. This study evaluated the targeting efficiency, efficacy, biodistribution, and potential toxicity of a rtPA covalently attached to chitosan-coated magnetic nanoparticles (chitosan-MNP-rtPA). The thrombolytic activity of a chitosan-MNP-rtPA was preserved by protection from an endogenous plasminogen activator inhibitor-1 (PAI-1) in whole blood and after circulation in vivo, as examined by thromboelastometry. Single-photon emission computed tomography (SPECT) demonstrated real-time retention of a

Indexed as

magnetic nanoparticlerecombinant tissue-type plasminogen activatortargeted thrombolysis

Identifiers

PMID38794257
PMCPMC11124959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.