Evidence map›Paper›PMID 38794216›Full record

ReviewPharmaceuticals (Basel, Switzerland)2024

Hive Products: Composition, Pharmacological Properties, and Therapeutic Applications.

Roberto Bava, Fabio Castagna, Carmine Lupia, Giusi Poerio, Giovanna Liguori, Renato Lombardi, Maria Diana Naturale, Rosa Maria Bulotta, Vito Biondi, Annamaria Passantino and 3 more

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Mechanism, Efficacy, and Safety of Natural Antibiotics.Antibiotics (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Roberto BavaDepartment of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy.ORCID 0000-0002-4173-8584
Fabio CastagnaDepartment of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy.ORCID 0000-0002-9600-6401
Carmine LupiaDepartment of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy.
Giusi PoerioATS Val Padana, Via dei Toscani, 46100 Mantova, Italy.
Giovanna LiguoriLocal Health Authority, ASL, 71121 Foggia, Italy.ORCID 0000-0002-3031-345X
Renato LombardiIRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013 Foggia, Italy.ORCID 0009-0005-7759-2141
Maria Diana NaturaleMinistry of Health, Directorate General for Health Programming, 00144 Rome, Italy.ORCID 0000-0002-5599-1265
Rosa Maria BulottaDepartment of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy.
Vito BiondiDepartment of Veterinary Sciences, University of Messina, 98168 Messina, Italy.ORCID 0000-0002-8717-1966
Annamaria PassantinoDepartment of Veterinary Sciences, University of Messina, 98168 Messina, Italy.ORCID 0000-0003-1701-3636
Domenico BrittiDepartment of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy.ORCID 0000-0001-7355-8791
Giancarlo StattiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036 Cosenza, Italy.ORCID 0000-0002-4780-452X
Ernesto PalmaDepartment of Health Sciences, University of Catanzaro Magna Græcia, 88100 Catanzaro, Italy.ORCID 0000-0003-4199-207X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beekeeping provides products with nutraceutical and pharmaceutical characteristics. These products are characterized by abundance of bioactive compounds. For different reasons, honey, royal jelly, propolis, venom, and pollen are beneficial to humans and animals and could be used as therapeutics. The pharmacological action of these products is related to many of their constituents. The main bioactive components of honey include oligosaccharides, methylglyoxal, royal jelly proteins (MRJPs), and phenolics compounds. Royal jelly contains jelleins, royalisin peptides, MRJPs, and derivatives of hydroxy-decenoic acid, particularly 10-hydroxy-2-decenoic acid (10-HDA), which possess antibacterial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome-preventing, and anti-aging properties. Propolis has a plethora of activities that are referable to compounds such as caffeic acid phenethyl ester. Peptides found in bee venom include phospholipase A2, apamin, and melittin. In addition to being vitamin-rich, bee pollen also includes unsaturated fatty acids, sterols, and phenolics compounds that express antiatherosclerotic, antidiabetic, and anti-inflammatory properties. Therefore, the constituents of hive products are particular and different. All of these constituents have been investigated for their properties in numerous research studies. This review aims to provide a thorough screening of the bioactive chemicals found in honeybee products and their beneficial biological effects. The manuscript may provide impetus to the branch of unconventional medicine that goes by the name of apitherapy.

Indexed as

apitherapybee venomhoneyhuman and animal healthpollenpropolisroyal jellytherapeutic properties

Identifiers

PMID38794216
PMCPMC11124102

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.