Evidence map›Paper›PMID 38794199›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

A Preliminary Investigation of Radiation-Sensitive Ultrasound Contrast Agents for Photon Dosimetry.

Bram Carlier, Sophie V Heymans, Sjoerd Nooijens, Gonzalo Collado-Lara, Yosra Toumia, Laurence Delombaerde, Gaio Paradossi, Jan D'hooge, Koen Van Den Abeele, Edmond Sterpin and 1 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bram CarlierDepartment of Oncology, KU Leuven-University of Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2450-3097
Sophie V HeymansDepartment of Physics, KU Leuven Campus Kortrijk-KULAK, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium.ORCID 0000-0002-8686-2247
Sjoerd NooijensDepartment of Cardiovascular Sciences, KU Leuven-University of Leuven, 3000 Leuven, Belgium.
Gonzalo Collado-LaraDepartment of Cardiology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-1010-6242
Yosra ToumiaNational Institute for Nuclear Physics, INFN Sezione di Roma Tor Vergata, 00133 Rome, Italy.
Laurence DelombaerdeDepartment of Oncology, KU Leuven-University of Leuven, 3000 Leuven, Belgium.
Gaio ParadossiDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-3051-3811
Jan D'hoogeDepartment of Cardiovascular Sciences, KU Leuven-University of Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2346-142X
Koen Van Den AbeeleDepartment of Physics, KU Leuven Campus Kortrijk-KULAK, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium.ORCID 0000-0003-0327-6478
Edmond SterpinDepartment of Oncology, KU Leuven-University of Leuven, 3000 Leuven, Belgium.
Uwe HimmelreichDepartment of Imaging and Pathology, KU Leuven-University of Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2060-8895

Funding

European Commission 766456 ("AMPHORA")Research Foundation - Flanders 11A9520NResearch Foundation - Flanders 12E0923N
6 · The paper itself

Abstract

Radiotherapy treatment plans have become highly conformal, posing additional constraints on the accuracy of treatment delivery. Here, we explore the use of radiation-sensitive ultrasound contrast agents (superheated phase-change nanodroplets) as dosimetric radiation sensors. In a series of experiments, we irradiated perfluorobutane nanodroplets dispersed in gel phantoms at various temperatures and assessed the radiation-induced nanodroplet vaporization events using offline or online ultrasound imaging. At 25 °C and 37 °C, the nanodroplet response was only present at higher photon energies (≥10 MV) and limited to <2 vaporization events per cm

Indexed as

dosimetrynanodropletsphase-change contrast agentradiotherapyultrasound imaging

Identifiers

PMID38794199
PMCPMC11125270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.