Synthesis and Evaluation of 5-(Heteroarylmethylene)hydantoins as Glycogen Synthase Kinase-3β Inhibitors.

Nicholas O Schneider, Kendra Gilreath, Daniel J Burkett, Martin St Maurice, William A Donaldson

Abstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present).Molecules (Basel, Switzerland) · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas O SchneiderDepartment of Biological Sciences, Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA.

Kendra GilreathDepartment of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA.

Daniel J BurkettDepartment of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA.

Martin St MauriceDepartment of Biological Sciences, Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA.

William A DonaldsonDepartment of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA.ORCID 0000-0002-0840-3731

Funding

Design, Synthesis and Evaluation of Inhibitors for Pyruvate CarboxylaseR15GM131356 · NIGMS · MARQUETTE UNIVERSITY · PI DONALDSON, WILLIAM A, ST. MAURICE, MARTIN RAOUL · 2019 to 2019

$459k

NIGMS NIH HHS R15 GM131356NIH HHS GM131356

6 · The paper itself

Abstract

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target. An ever-increasing number of small organic molecule inhibitors of GSK-3 have been reported. Phenylmethylene hydantoins are known to exhibit a wide range of inhibitory activities including for GSK-3β. A family of fourteen 2-heterocycle substituted methylene hydantoins (

Indexed as

computational dockingglycogen synthase kinase 3βnitrogen heterocycles

Identifiers

PMID38794140

DOI10.3390/ph17050570

PMCPMC11123921

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.