Evidence map›Paper›PMID 38793786›Full record

ArticleVaccines2024

MV140 Mucosal Vaccine Induces Targeted Immune Response for Enhanced Clearance of Uropathogenic

Paula Saz-Leal, Marianne Morris Ligon, Carmen María Diez-Rivero, Diego García-Ayuso, Soumitra Mohanty, Marcos Viñuela, Irene Real-Arévalo, Laura Conejero, Annelie Brauner, José Luis Subiza and 1 more

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Paula Saz-LealInmunotek S.L., 28805 Madrid, Spain.ORCID 0000-0002-6263-4709
Marianne Morris LigonDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6632-1163
Carmen María Diez-RiveroInmunotek S.L., 28805 Madrid, Spain.
Diego García-AyusoInmunotek S.L., 28805 Madrid, Spain.
Soumitra MohantyDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Marcos ViñuelaInmunotek S.L., 28805 Madrid, Spain.ORCID 0009-0002-8338-1832
Irene Real-ArévaloInmunotek S.L., 28805 Madrid, Spain.
Laura ConejeroInmunotek S.L., 28805 Madrid, Spain.ORCID 0000-0001-6515-9221
Annelie BraunerDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
José Luis SubizaInmunotek S.L., 28805 Madrid, Spain.ORCID 0000-0002-0134-5321
Indira Uppugunduri MysorekarDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
INTERLEUKIN-6 AND AGING: IMPACT ON IMMUNE DEFENSE AND TISSUE REPAIR IN URINARY BLADDERR01AG052494 · NIA · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, MYSOREKAR, INDIRA U · 2016 to 2020
$1.6M
Mechanism of age-associated inflammation and lymphoid neogenesis in the urinary bladderR56AG064634 · NIA · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, MYSOREKAR, INDIRA U · 2019 to 2019
$625k
Molecular and neuro-inflammatory biology of aging bladder in normal and disease states: ProjectP20DK119840 · NIDDK · WASHINGTON UNIVERSITY · PI MYSOREKAR, INDIRA U · 2018 to 2019
$612k
NIAID NIH HHS T32 AI007172NIA NIH HHS R01 AG052494NIA NIH HHS R56 AG064634NIDDK NIH HHS P20 DK119840NIGMS NIH HHS T32 GM007200
6 · The paper itself

Abstract

MV140 is an inactivated whole-cell bacterial mucosal vaccine with proven clinical efficacy against recurrent urinary tract infections (UTIs). These infections are primarily caused by uropathogenic

Indexed as

mucosal immunityMV140UPEC—uropathogenic E. coliUTI89UTI—urinary tract infectionvaccine

Identifiers

PMID38793786
PMCPMC11126127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.