Evidence map›Paper›PMID 38793781›Full record

ReviewVaccines2024

Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of Mycobacteria.

Raja Veerapandian, Shrikanth S Gadad, Chinnaswamy Jagannath, Subramanian Dhandayuthapani

Abstract readReview
In one paragraph

Review in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Construction and characterization of novelInfection and immunity · 2026
    Article
  2. Review
  3. Review
  4. Autophagy andFrontiers in cellular and infection microbiology · 2026
    Review
  5. Article
  6. Article
  7. Long non-coding RNA transcripts inNon-coding RNA research · 2025
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raja VeerapandianCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.ORCID 0000-0003-1118-0038
Shrikanth S GadadCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.ORCID 0000-0003-0030-5472
Chinnaswamy JagannathDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute & Weill Cornell Medical College, Houston, TX 77030, USA.
Subramanian DhandayuthapaniCenter of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.

Funding

Novel Stem Cell Immunotherapy for MDR-TuberculosisR01AI161015 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ENDSLEY, JANICE J, JAGANNATH, CHINNASWAMY · 2021 to 2025
$4.8M
Chracteristics of An M. Tuberculosis Derived VaccineR01AI049534 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JAGANNATH, CHINNASWAMY · 2002 to 2011
$3.4M
Mechanisms of Mycobacterial Antigen ProcessingR01AI078420 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JAGANNATH, CHINNASWAMY · 2009 to 2013
$2.2M
A Novel Hyper-Immunogenic Low Virulent BCG vaccine against TuberculosisR01AI175837 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SUBRAMANIAN DHANDAYUTHAPANI · 2023 to 2026
$2.0M
A novel quadruple knockout MTb vaccine against tuberculosis (Supplement Resubmission)R15AI156647 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO · PI DHANDAYUTHAPANI, SUBRAMANIAN · 2021 to 2023
$626k
Analysis of Divergent Transcripts in Estrogen-Dependent SignalingR16GM149497 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Shrikanth Gadad · 2023 to 2026
$620k
Promotion of HIV-1 transinfection by Mycoplasma genitaliumR21AI089346 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DHANDAYUTHAPANI, SUBRAMANIAN · 2010 to 2011
$394k
NIAID NIH HHS R01 AI161015NIAID NIH HHS R01 AI175837NIAID NIH HHS R15 AI156647NIGMS NIH HHS R16 GM149497NIH HHS R01AI175837, RO1AI138587, R01AI161015, R16GM149497NIH HHS R15AI156647
6 · The paper itself

Abstract

Tuberculosis (TB), a chronic infectious disease affecting humans, causes over 1.3 million deaths per year throughout the world. The current preventive vaccine BCG provides protection against childhood TB, but it fails to protect against pulmonary TB. Multiple candidates have been evaluated to either replace or boost the efficacy of the BCG vaccine, including subunit protein, DNA, virus vector-based vaccines, etc., most of which provide only short-term immunity. Several live attenuated vaccines derived from

Indexed as

BCGgene knockoutlive attenuated vaccines (LAVs)Mycobacterium tuberculosissecretory antigenstuberculosis

Identifiers

PMID38793781
PMCPMC11126151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.