Evidence map›Paper›PMID 38793744›Full record

ArticleVaccines2024

The Equal Neutralizing Effectiveness of BNT162b2, ChAdOx1 nCoV-19, and Sputnik V Vaccines in the Palestinian Population.

Alexia Damour, Muriel Faure, Nicolas Landrein, Jessica Ragues, Narda Ardah, Haneen Dhaidel, Marie-Edith Lafon, Harald Wodrich, Walid Basha

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexia DamourCNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University Bordeaux, 33076 Bordeaux, France.
Muriel FaureCNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-2013-5776
Nicolas LandreinCNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University Bordeaux, 33076 Bordeaux, France.ORCID 0000-0001-8875-4242
Jessica RaguesCNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University Bordeaux, 33076 Bordeaux, France.
Narda ArdahIBGC, UMR 5095, CNRS UMR 5095, Institute of Cellular Biochemistry and Genetics, Université of Bordeaux, 33077 Bordeaux, France.
Haneen DhaidelDepartment of Applied and Allied Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus P400, Palestine.
Marie-Edith LafonCNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University Bordeaux, 33076 Bordeaux, France.ORCID 0000-0001-6974-177X
Harald WodrichCNRS UMR 5234, Fundamental Microbiology and Pathogenicity, University Bordeaux, 33076 Bordeaux, France.ORCID 0000-0002-4764-1708
Walid BashaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus P400, Palestine.ORCID 0000-0003-1883-3097

Funding

Agence universitaire de la Francophonie (AUF) DRMO - 6744institutional funds Projet 2818
6 · The paper itself

Abstract

Since the beginning of the COVID-19 pandemic, different viral vector-based and mRNA vaccines directed against the SARS-CoV-2 "S" spike glycoprotein have been developed and have shown a good profile in terms of safety and efficacy. Nevertheless, an unbiased comparison of vaccination efficiency, including post-vaccination neutralizing activity, between the different vaccines remains largely unavailable. This study aimed to compare the efficacy of one mRNA (BNT162b2) and two non-replicating adenoviral vector vaccines (ChAdOx1 nCoV-19 and Sputnik V) in a cohort of 1120 vaccinated Palestinian individuals who received vaccines on an availability basis and which displayed a unique diversity of genetic characteristics. We assessed the level of anti-S antibodies and further determined the antibody neutralizing activity in 261 of those individuals vaccinated with BNT162b2a (121), ChAdOx1 (72) or Sputnik V (68). Our results showed no significant difference in the distribution of serum-neutralizing activity or S-antibody serum levels for the three groups of vaccines, proving equivalence in efficacy for the three vaccines under real-life conditions. In addition, none of the eight demographic parameters tested had an influence on vaccination efficacy. Regardless of the vaccine type, the vaccination campaign ultimately played a pivotal role in significantly reducing the morbidity and mortality associated with COVID-19 in Palestine.

Indexed as

adenovirus vaccinemRNA vaccineneutralizing antibodiesPalestineSARS-CoV-2vaccination

Identifiers

PMID38793744
PMCPMC11125902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.