Evidence map›Paper›PMID 38793623›Full record

ArticleViruses2024

Cytokine Response of Natural Killer Cells to Hepatitis B Virus Infection Depends on Monocyte Co-Stimulation.

Paul Kupke, Johanna Brucker, Jochen M Wettengel, Ulrike Protzer, Jürgen J Wenzel, Hans J Schlitt, Edward K Geissler, Jens M Werner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul KupkeDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-8007-5787
Johanna BruckerDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.
Jochen M WettengelInstitute of Virology, School of Medicine and Health/Helmholtz Munich, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-4101-9280
Ulrike ProtzerInstitute of Virology, School of Medicine and Health/Helmholtz Munich, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-9421-1911
Jürgen J WenzelInstitute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0001-8422-6581
Hans J SchlittDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-3874-0296
Edward K GeisslerDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.
Jens M WernerDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0001-7156-4370

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) is a major driver of chronic hepatic inflammation, which regularly leads to liver cirrhosis or hepatocellular carcinoma. Immediate innate immune cell response is crucial for the rapid clearance of the infection. Here, natural killer (NK) cells play a pivotal role in direct cytotoxicity and the secretion of antiviral cytokines as well as regulatory function. The aim of this study was to further elucidate NK cell responses triggered by an HBV infection. Therefore, we optimized HBV in vitro models that reliably stimulate NK cells using hepatocyte-like HepG2 cells expressing the Na

Indexed as

Coculture TechniquesCytokinesHepatitis BHepatitis B virusKiller Cells, NaturalMonocytesHepatocytesHep G2 CellsHumansInterferon-gammaTumor Necrosis Factor-alphaVirus ReplicationCytokinesInterferon-gammaTumor Necrosis Factor-alphabystander activationHBVHepaRGhepatitis B virusHepG2monocytesnatural killer cellsNK cellsNTCP

Identifiers

PMID38793623
PMCPMC11125674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.