ReviewJournal of personalized medicine2024
Misdiagnosis and Clinical Insights into Acral Amelanotic Melanoma-A Systematic Review.
Review in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Seen on screen, missed in clinic: educational pearls fromSkin health and disease · 2026Review
- Atypical Melanoma of the Lateral Fifth Metatarsal Shaft: A Rare Presentation With Minimal Mitotic Activity.Cureus · 2026Article
- Masked pressure lesion on the tip of the toe, a diagnostic challenge : Case report.Wiener klinische Wochenschrift · 2026Article
- A Comprehensive Analysis of the Blurring Boundary Between Cosmetic Applications and Medical Treatment.Journal of cosmetic dermatology · 2026Review
- Integrating features of radiomics and CNN models for early skin cancer detection based on watershed segmentation.Discover oncology · 2026Article
- Diagnostic challenges and importance of early multidisciplinary intervention in acral melanoma: a case report.Dermatology reports · 2026Article
- A 76-year-old man with hemoptysis and a groin nodule: A case report.SAGE open medical case reports · 2026Article
- Translating Features to Findings: Deep Learning for Melanoma Subtype Prediction.Dermatopathology (Basel, Switzerland) · 2025Review
- Therapeutic Opportunities in Melanoma Through PRAME Expression.Biomedicines · 2025Review
- Acral Amelanotic Melanoma With a Sporotrichoid Pattern and Associated Vitiligo in an Elderly Patient: A Case Report.Cureus · 2025Article
- Factors Contributing to the False Diagnosis of Misleading Dermatofibromas.Cancer reports (Hoboken, N.J.) · 2025Article
- Congenital Dermatofibrosarcoma Protuberans-An Update on the Ongoing Diagnostic Challenges.Cancers · 2025Review
- Case Report: Imaging findings in sneaky subungual amelanotic melanoma.Frontiers in medicine · 2025Article
- Rare subungual amelanotic melanoma presenting as prolonged swelling and exudation after trauma: case report and literature review.Frontiers in immunology · 2025Review
- Angiomatoid Fibrous Histiocytoma Initially Misdiagnosed as Elastofibroma Dorsi: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2024Review
- Amelanotic Melanoma-Biochemical and Molecular Induction Pathways.International journal of molecular sciences · 2024Review
- A Narrative Review of the Evolution of Diagnostic Techniques and Treatment Strategies for Acral Lentiginous Melanoma.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcral amelanotic melanomas (AAMs), a rare subset of melanomas located on acral sites such as the palms, soles, and subungual areas, are diagnostically challenging due to their lack of typical pigmentation and often benign clinical appearance. Misdiagnosis is common, leading to delays in treatment and potentially worse outcomes. This systematic review aims to synthesise evidence on cases of AAM initially misdiagnosed as other conditions, to better understand their clinical and epidemiological characteristics, diagnostic pitfalls, and management strategies.
methodsA comprehensive search of the MEDLINE/PubMed, EMBASE, and SCOPUS databases was conducted up to March 2024. Case reports and small case series of AAMs initially misdiagnosed as other conditions were included. Data on patient demographics, clinical presentation, and diagnostic methods were collected and analyzed.
resultsOf the 152 records identified, 26 cases from 23 articles met the inclusion criteria. A demographic analysis revealed that the gender distribution appears to be perfectly balanced, with an age range of 38 to 91 years. Misdiagnoses included non-healing ulcers or traumatic lesions (37.5%), benign proliferative lesions (29.2%) and infectious lesions (20.8%). The foot was the most affected site (53.8%). Notably, a histological evaluation was performed in 50% of cases involving the upper extremities, in contrast to only 7.1% of cases involving the foot and 0% of cases of the heel. This discrepancy suggests a reluctance to perform biopsies in the lower extremities, which may contribute to a higher misdiagnosis rate in these areas.
conclusionsThe underutilization of biopsy in the diagnosis of lower extremity lesions contributes significantly to the misdiagnosis and delay in treatment of AAMs. Especially when the clinical assessment and dermoscopy are inconclusive, biopsies of suspicious lesions are essential. Immunohistochemistry and markers such as PRAME are critical in differentiating melanoma from other malignancies such as clear cell sarcoma. This review highlights the need for increased vigilance and a proactive diagnostic approach to increase early detection rates and improve prognostic outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.