Evidence map›Paper›PMID 38793089›Full record

ReviewJournal of personalized medicine2024

Exploring the Gut Microbiome's Role in Inflammatory Bowel Disease: Insights and Interventions.

Despoina Gyriki, Christos Nikolaidis, Elisavet Stavropoulou, Ioanna Bezirtzoglou, Christina Tsigalou, Stergios Vradelis, Eugenia Bezirtzoglou

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Despoina GyrikiMaster Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0009-0008-5439-2149
Christos NikolaidisInternal Medicine Department, Vostaneio-General Hospital of Mytilene, 81100 Mytilene, Greece.ORCID 0000-0001-6271-5595
Elisavet StavropoulouMaster Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Ioanna BezirtzoglouDepartment of Chemistry, Imperial College London, London SW7 2AZ, UK.
Christina TsigalouMaster Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-7869-6824
Stergios VradelisMaster Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0009-0004-1846-8186
Eugenia BezirtzoglouMaster Program in "Food, Nutrition and Microbiome", Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-2010-2544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory Bowel Disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition of the intestine that significantly impairs quality of life and imposes a heavy burden on healthcare systems globally. While the exact etiology of IBD is unclear, it is influenced by genetic, environmental, immunological, and microbial factors. Recent advances highlight the gut microbiome's pivotal role in IBD pathogenesis. The microbial dysbiosis characteristic of IBD, marked by a decline in beneficial bacteria and an increase in pathogenic microbes, suggests a profound connection between microbial imbalance and disease mechanisms. This review explores diagnostic approaches to IBD that integrate clinical assessment with advanced microbiological analyses, highlighting the potential of microbiome profiling as a non-invasive diagnostic tool. In addition, it evaluates conventional and emerging treatments and discusses microbiome-targeted intervention prospects, such as probiotics, symbiotics, and faecal microbiota transplantation. The necessity for future research to establish their efficacy and safety is emphasised.

Indexed as

faecal microbiota transplantationinflammatory bowel diseasemicrobiomeprebioticsprobioticssymbiotics

Identifiers

PMID38793089
PMCPMC11122163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.