ArticleLife (Basel, Switzerland)2024
The Association of Central Sensitisation with Depression, Anxiety, and Somatic Symptoms: A Cross-Sectional Study of a Mental Health Outpatient Clinic in Japan.
Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychosocial factors as predictors of headache chronification: A systematic review and meta-analysis of longitudinal studies.Headache · 2026Pooled it
- Psychosocial and Functional Determinants of Central Sensitisation in Patients with Behçet's Disease: A Cross-Sectional Study.Mediterranean journal of rheumatology · 2026Article
- Effect of co-morbid anxiety and depression history on multidomain concussion clinical outcomes and recovery time.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Prevalence of Central Sensitization in Postural Tachycardia Syndrome.JAMA network open · 2026Article
- Beyond device parameters: psychological predictors of spinal cord stimulation success and their neurobiological mechanisms-a narrative review.Frontiers in psychology · 2026Review
- Timing of depressive episode onset relative to chronic pain reveals distinct patterns of affective and multisite pain.Frontiers in psychiatry · 2026Article
- Burning mouth syndrome: updates on pathogenesis and diagnostic algorithms.Journal of oral & facial pain and headache · 2025Review
- Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Panic attack symptoms in patients with diabetic peripheral neuropathy.Comprehensive psychoneuroendocrinology · 2025Article
- Comparison of Depression in Hemodialysis, Peritoneal Dialysis, and Kidney Transplant Patients: A Systematic Review with Meta-Analysis.Journal of personalized medicine · 2025Review
- Prevalence of central sensitization and somatization in adults with temporomandibular disorders-a prospective observational study.Journal of oral & facial pain and headache · 2024Observational
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Authors and funding
5 authors.
Funding
Abstract
For patients with chronic pain and persistent physical symptoms, understanding the mechanism of central sensitisation may help in understanding how symptoms persist. This cross-sectional study investigated the association of central sensitisation with depression, anxiety, and somatic symptoms. Four hundred and fifteen adults attending an outpatient psychosomatic clinic were evaluated. Participants completed the Hospital Anxiety and Depression Scale, Somatic Symptom Scale 8, and the Central Sensitisation Inventory. The relationships between these factors were examined using descriptive statistics and multiple logistic regression analyses. The mean age was 42.3 years, and 59% were female. The disorders included adjustment disorders (n = 70), anxiety disorders (n = 63), depressive disorders (n = 103), feeding and eating disorders (n = 30), sleep-wake disorders (n = 37), somatic symptoms and related disorders (n = 84), and others (n = 28). In multiple logistic regression analyses, higher central sensitisation was associated with more severe anxiety, depression, and somatic symptoms after controlling for potential confounders. In the disease-specific analysis, somatic symptoms correlated more positively with central sensitisation than with depression or anxiety. Central sensitisation and depression, anxiety, and somatic symptoms were associated with patients attending an outpatient clinic. These findings highlight the importance of evaluating depression, anxiety, and somatic symptoms when assessing central sensitisation.
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