Evidence map›Paper›PMID 38792153›Full record

ArticleMolecules (Basel, Switzerland)2024

Lactic Acid Bacteria-Derived Postbiotics as Adjunctive Agents in Breast Cancer Treatment to Boost the Antineoplastic Effect of a Conventional Therapeutic Comprising Tamoxifen and a New Drug Candidate: An Aziridine-Hydrazide Hydrazone Derivative.

Joanna Wasiak, Pola Głowacka, Agnieszka Pudlarz, Adam M Pieczonka, Katarzyna Dzitko, Janusz Szemraj, Monika Witusik-Perkowska

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Observational
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joanna WasiakDepartment of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.
Pola GłowackaDepartment of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.
Agnieszka PudlarzDepartment of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.ORCID 0000-0001-5935-7432
Adam M PieczonkaDepartment of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12 Str., 91-403 Lodz, Poland.ORCID 0000-0001-6526-315X
Katarzyna DzitkoDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16 Str., 90-237 Lodz, Poland.ORCID 0000-0002-3265-0409
Janusz SzemrajDepartment of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.ORCID 0000-0001-6052-3557
Monika Witusik-PerkowskaDepartment of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.ORCID 0000-0002-8556-2859

Funding

National Science Center 2022/47/O/NZ7/01089
6 · The paper itself

Abstract

Breast cancer is associated with high mortality and morbidity rates. As about 20-30% of patients exhibiting ER-positive phenotype are resistant to hormonal treatment with the standard drug tamoxifen, finding new therapies is a necessity. Postbiotics, metabolites, and macromolecules isolated from probiotic bacteria cultures have been proven to have sufficient bioactivity to exert prohealth and anticancer effects, making them viable adjunctive agents for the treatment of various neoplasms, including breast cancer. In the current study, postbiotics derived from

Indexed as

ApoptosisAziridinesBreast NeoplasmsCell ProliferationTamoxifenAntineoplastic AgentsCell CycleCell SurvivalFemaleHumansHydrazonesMCF-7 CellsProbioticsAntineoplastic AgentsaziridineAziridinesHydrazonesTamoxifenadjunctive therapyaziridine–hydrazide hydrazonesbreast cancerlactic acid bacteriaL. plantarumL. rhamnosuspostbioticstamoxifen

Identifiers

PMID38792153
PMCPMC11124249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.