Evidence map›Paper›PMID 38792119›Full record

ArticleMolecules (Basel, Switzerland)2024

Comparative Studies of Bioactivities and Chemical Components in Fresh and Black Garlics.

Kanako Matsuse, Sho Hirata, Mostafa Abdelrahman, Tetsuya Nakajima, Yoshihito Iuchi, Satoshi Kambayashi, Masaru Okuda, Kimiko Kazumura, Benya Manochai, Masayoshi Shigyo

Abstract readComparative Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kanako MatsuseDivision of Yamaguchi University and Kasetsart University Joint Master's Degree Program in Agricultural and Life Sciences, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
Sho HirataLaboratory of Agroecology, Department of Bioresource Sciences, Faculty of Agriculture, Kyushu University, Motooka, Nishi-ku, Fukuoka 819-0395, Japan.ORCID 0000-0003-0187-0983
Mostafa AbdelrahmanInstitute of Genomics for Crop Abiotic Stress Tolerance, 1006 Canton Ave, Lubbock, TX 79409, USA.
Tetsuya NakajimaGraduate School of Sciences and Technology for Innovation, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
Yoshihito IuchiGraduate School of Sciences and Technology for Innovation, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
Satoshi KambayashiLaboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
Masaru OkudaLaboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.ORCID 0000-0003-4690-8244
Kimiko KazumuraGlobal Strategic Challenge Center, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamana-ku, Hamamatsu 434-8601, Japan.ORCID 0000-0002-8628-5785
Benya ManochaiDepartment of Horticulture, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand.
Masayoshi ShigyoGraduate School of Sciences and Technology for Innovation, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.ORCID 0000-0003-4014-6613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the bioactivities of fresh garlic and its processed product, black garlic, we conducted comparative analyses of antioxidant, anti-inflammatory, innate immune activation, and anti-cancer activities in addition to the chemical composition (sugar, amino acid, and polyphenol contents) of these materials. Simultaneous assay using neutrophil-like cells showed that fresh garlic exhibited antioxidant and innate immunostimulatory activities, whereas black garlic displayed a potent anti-inflammatory effect. The antioxidant activity index was correlated with phenol and flavonoid contents, while the innate immunostimulatory activity was correlated with fructan content. Furthermore, some black garlics with low fructose content were found to inhibit the proliferation of UM-UC-3 cancer cells, while other black garlics rich in fructose increased UM-UC-3 cell proliferation. It was shown that the processing of fresh garlic could change the composition of sugars, antioxidants, and amino acids, which have different effects on neutrophil-like cells and UM-UC-3 cells, as well as on bioactivities.

Indexed as

AntioxidantsCell ProliferationGarlicAmino AcidsAnti-Inflammatory AgentsCell Line, TumorFlavonoidsHumansNeutrophilsPhenolsPlant ExtractsPolyphenolsAmino AcidsAnti-Inflammatory AgentsAntioxidantsFlavonoidsPhenolsPlant ExtractsPolyphenolsAllium sativumanticancer activityblack garlicfunctional foodprocessed food

Identifiers

PMID38792119
PMCPMC11124420

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.