Turn-on Coumarin Precursor: From Hydrazine Sensor to Covalent Inhibition and Fluorescence Detection of Rabbit Muscle Aldolase.

Sara Amer, Uri Miles, Michael Firer, Flavio Grynszpan

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara AmerDepartment of Chemical Sciences, Ariel University, 65 Ramat HaGolan Street, Ariel 4077625, Israel.

Uri MilesDepartment of Chemical Sciences, Ariel University, 65 Ramat HaGolan Street, Ariel 4077625, Israel.

Michael FirerDepartment of Chemical Engineering and Biotechnology, Ariel University, Ariel 4077625, Israel.ORCID 0000-0002-8430-0486

Flavio GrynszpanDepartment of Chemical Sciences, Ariel University, 65 Ramat HaGolan Street, Ariel 4077625, Israel.ORCID 0000-0003-2445-5416

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrazine, a highly toxic compound, demands sensitive and selective detection methods. Building upon our previous studies with pre-coumarin OFF-ON sensors for fluoride anions, we extended our strategy to hydrazine sensing by adapting phenol protecting groups (propionate, levulinate, and γ-bromobutanoate) to our pre-coumarin scaffold. These probes reacted with hydrazine, yielding a fluorescent signal with low micromolar limits of detection. Mechanistic studies revealed that hydrazine deprotection may be outperformed by a retro-Knoevenagel reaction, where hydrazine acts as a nucleophile and a base yielding a fluorescent diimide compound (6,6'-((1

Indexed as

CoumarinsHydrazinesAnimalsFluorescenceFluorescent DyesMolecular StructureMusclesRabbitscoumarinCoumarinsFluorescent DyeshydrazineHydrazinesaldolase inhibitorcoumarinfluorescent detectionhydrazine sensortheranosticsturn-on

Identifiers

PMID38792037

DOI10.3390/molecules29102175

PMCPMC11123778

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.