Evidence map›Paper›PMID 38792002›Full record

ArticleCancers2024

Neuropilin2 in Mesenchymal Stromal Cells as a Potential Novel Therapeutic Target in Myelofibrosis.

Karla Vosbeck, Sarah Förster, Thomas Mayr, Anshupa Sahu, El-Mustapha Haddouti, Osamah Al-Adilee, Ruth-Miriam Körber, Savita Bisht, Michael H Muders, Svetozar Nesic and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Karla VosbeckInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Sarah FörsterInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Thomas MayrInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-2900-1782
Anshupa SahuInstitute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-0305-6283
El-Mustapha HaddoutiDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.
Osamah Al-AdileeInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Ruth-Miriam KörberDepartment of Medicine III, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-8773-8221
Savita BishtDepartment of Medicine III, University Hospital Bonn, 53127 Bonn, Germany.
Michael H MudersInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.
Svetozar NesicCore Unit for Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Andreas BunessCore Unit for Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Glen KristiansenInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-4149-5487
Frank A SchildbergDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-0797-1945
Ines GütgemannInstitute for Pathology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-2609-3095

Funding

Rudolf Becker Foundation; aTyr Pharma; BONFOR O-155.0072
6 · The paper itself

Abstract

Bone marrow fibrosis in myeloproliferative neoplasm (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap syndromes and acute myeloid leukemia (AML) is associated with poor prognosis and early treatment failure. Myelofibrosis (MF) is accompanied by reprogramming of multipotent bone marrow mesenchymal stromal cells (MSC) into osteoid and fiber-producing stromal cells. We demonstrate NRP2 and osteolineage marker NCAM1 (neural cell adhesion molecule 1) expression within the endosteal niche in normal bone marrow and aberrantly in MPN, MDS MPN/MDS overlap syndromes and AML (

Indexed as

endosteal nichemesenchymal stromal cellsmyelofibrosismyeloproliferative neoplasmneuropilin 2

Identifiers

PMID38792002
PMCPMC11119673

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.