Evidence map›Paper›PMID 38791963›Full record

ArticleCancers2024

TIM-3 Expression on Dendritic Cells in Colorectal Cancer.

Mei Sakuma, Masanori Katagata, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Takahiro Sato, Satoshi Fukai, Hideaki Tsumuraya, Hisashi Onozawa, Wataru Sakamoto and 5 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  5. Article
  6. Spatial patterns and prognostic relevance of CD1aCancer immunology, immunotherapy : CII · 2025
    Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mei SakumaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Masanori KatagataDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Hirokazu OkayamaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0003-0966-4746
Shotaro NakajimaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0002-9339-3792
Katsuharu SaitoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Takahiro SatoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Satoshi FukaiDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Hideaki TsumurayaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Hisashi OnozawaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Wataru SakamotoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Motonobu SaitoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0001-5072-3520
Zenichiro SazeDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Tomoyuki MommaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.
Kosaku MimuraDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0003-2565-154X
Koji KonoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima 960-1295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TIM-3 was originally identified as a negative regulator of helper T cells and is expressed on dendritic cells (DCs). Since the inhibition of TIM-3 on DCs has been suggested to enhance T cell-mediated anti-tumor immunity, we examined its expression on DCs within the tumor microenvironment (TME) in colorectal cancer (CRC) using transcriptomic data from a public database (

Indexed as

cGAS-STINGcolorectal cancerdendritic cellimmunotherapyTIM-3

Identifiers

PMID38791963
PMCPMC11120027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.