Evidence map›Paper›PMID 38791940›Full record

ArticleCancers2024

Molecular Characterization and Therapeutic Opportunities in KRAS Wildtype Pancreatic Ductal Adenocarcinoma.

Aakash Desai, Alexander H Xiao, Daheui Choi, Merih D Toruner, Daniel Walden, Thorvardur R Halfdanarson, Steven Alberts, Robert R McWilliams, Amit Mahipal, Daniel Ahn and 9 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. GSK3βGut · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Aakash DesaiDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.
Alexander H XiaoDepartment of Medicine, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-8929-9798
Daheui ChoiDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55902, USA.
Merih D TorunerDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-7447-8654
Daniel WaldenDivision of Hematology and Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Thorvardur R HalfdanarsonDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-8460-1257
Steven AlbertsDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.
Robert R McWilliamsDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.
Amit MahipalDepartment of Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.ORCID 0000-0002-1111-8333
Daniel AhnDivision of Hematology and Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Hani BabikerDivision of Hematology and Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Gulnaz StybayevaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-1453-245X
Alexander RevzinDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55902, USA.
Sani KizilbashDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.
Alex AdjeiTaussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Tanios Bekaii-SaabDivision of Hematology and Oncology, Mayo Clinic, Phoenix, AZ 85054, USA.
Aaron S MansfieldDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-9483-6903
Ryan M CarrDepartment of Oncology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-5762-367X
Wen Wee MaTaussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the molecular characteristics of and potential for precision medicine in KRAS wildtype pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND

methodsWe investigated 27 patients with

resultsTranscriptomic analysis showed our cohort may be stratified by the relative gene expression of the KRAS signaling cascade. The PDO derived from our patient harboring a

conclusions

Indexed as

APL-101KRAS wildtypeMET fusionpancreatic ductal adenocarcinomaPLB1001vebreltinib

Identifiers

PMID38791940
PMCPMC11119482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.