Evidence map›Paper›PMID 38791896›Full record

ArticleCancers2024

Ki67 Tumor Expression Predicts Treatment Benefit Achieved by Macroscopic Radical Lung-Preserving Surgery in Pleural Mesothelioma-A Retrospective Multicenter Analysis.

Sarah Hintermair, Stephanie Iser, Alexander Varga, Melanie Biesinger, Tomas Bohanes, Ali Celik, Muhammet Sayan, Aykut Kankoç, Nalan Akyurek, Betul Öğüt and 2 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah HintermairKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Stephanie IserKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Alexander VargaDepartment of Pathology, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria.
Melanie BiesingerKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Tomas BohanesKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Ali CelikDepartment of Thoracic Surgery, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.
Muhammet SayanDepartment of Thoracic Surgery, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.ORCID 0000-0002-5402-9031
Aykut KankoçDepartment of Thoracic Surgery, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.
Nalan AkyurekDepartment of Pathology, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.ORCID 0000-0002-2644-4609
Betul ÖğütDepartment of Pathology, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.
Elisabeth StubenbergerKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Bahil GhanimKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.ORCID 0000-0002-6563-5643

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleural mesothelioma (PM), linked to asbestos-induced inflammation, carries a poor prognosis. Therapy ranges from therapy limitation to aggressive multimodality treatment. Given the uncertainty about treatment benefits for patients, this study aimed to assess the role of Ki67 as a prognostic and predictive parameter in PM. Ki67 was measured in the specimens of 70 PM patients (17 female, 53 male) from two centers and correlated to overall survival (OS) and therapy outcome. The median OS was 16.1 months. The level of Ki67 expression was divided into low (≤15%) and high (>15%). A low value of Ki67 expression was associated with a longer OS (Ki67 ≤ 15%: 31.2 (95% CI 6.5-55.8) months vs. Ki67 > 15%: 11.1 (95% CI 7.7-14.6) months,

Indexed as

cytoreductive surgeryinflammationKi67 indexlung-sparing surgerymacroscopic complete resectionmultimodality treatmentpleural mesotheliomapredictive biomarkerprognostic biomarker

Identifiers

PMID38791896
PMCPMC11119444

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.