Evidence map›Paper›PMID 38791584›Full record

ArticleInternational journal of molecular sciences2024

Neuregulin 2 Is a Candidate Gene for Autism Spectrum Disorder.

Wei-Hsien Chien, Chia-Hsiang Chen, Min-Chih Cheng, Yu-Yu Wu, Susan Shur-Fen Gau

Abstract read
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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei-Hsien ChienDepartment of Occupational Therapy, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Chia-Hsiang ChenDepartment of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.ORCID 0000-0002-8232-2403
Min-Chih ChengDepartment of Psychiatry, Yuli Branch, Taipei Veterans General Hospital, Hualien 981, Taiwan.
Yu-Yu WuDepartment of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Susan Shur-Fen GauDepartment of Psychiatry, National Taiwan University Hospital, Taipei 10002, Taiwan.

Funding

National Science and Technology Council NSC96-3112-B-002-033, NSC97-3112-B-002-009, NSC98-3112-B-002-004, NSC 99-3112-B-002-036, MOST 103-2314-B-002-055-MY3, MOST 109-2327-B-002 -004, MOST 110-2327-B-002 -006, MOST 111-2327-B-002 -009, and NSC 107-2635-B-030-002
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with heterogeneous and complex genetic underpinnings. Our previous microarray gene expression profiling identified significantly different neuregulin-2 gene (NRG2) expression between ASD patients and controls. Thus, we aimed to clarify whether NRG2 is a candidate gene associated with ASD. The study consisted of two stages. First, we used real-time quantitative PCR in 20 ASDs and 20 controls to confirm the microarray gene expression profiling results. The average NRG2 gene expression level in patients with ASD (3.23 ± 2.80) was significantly lower than that in the controls (9.27 ± 4.78,

Indexed as

Autism Spectrum DisorderGenetic Predisposition to DiseaseNeuregulinsAdolescentAdultCase-Control StudiesChildExonsFemaleGene Expression ProfilingGene FrequencyGenetic Association StudiesHumansMaleNerve Growth FactorsPolymorphism, Single NucleotideNerve Growth FactorsNeuregulinsNRG2 protein, humanautism spectrum disordersinsertion/deletion polymorphism (indel)neuregulin 2 (NRG2)

Identifiers

PMID38791584
PMCPMC11121989

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.