Evidence map›Paper›PMID 38791557›Full record

ArticleInternational journal of molecular sciences2024

Cytosine Deaminase-Overexpressing hTERT-Immortalized Human Adipose Stem Cells Enhance the Inhibitory Effects of Fluorocytosine on Tumor Growth in Castration Resistant Prostate Cancer.

Jae Heon Kim, Hee Jo Yang, Sang Hun Lee, Yun Seob Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jae Heon KimDepartment of Urology, Soonchunhyang University School of Medicine, Seoul 04401, Republic of Korea.
Hee Jo YangDepartment of Urology, Soonchunhyang University School of Medicine, Cheonan 31151, Republic of Korea.ORCID 0000-0002-7195-806X
Sang Hun LeeProgram in Biomedical Sciences & Engineering, Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22212, Republic of Korea.
Yun Seob SongDepartment of Urology, Soonchunhyang University School of Medicine, Seoul 04401, Republic of Korea.

Funding

National Research Foundation of Korea 2021R1A2C1004163Soonchunhyang University 2021021212
6 · The paper itself

Abstract

A promising de novo approach for the treatment of Castration-resistant prostate cancer (CRPC) exploits cell-mediated enzyme prodrug therapy comprising cytosine deaminase (CD) and fluorouracil (5-FC). The aim of this study was to determine the potential of bacterial CD-overexpressing hTERT-immortalized human adipose stem cells (hTERT-ADSC.CD) to suppress CRPC. A lentiviral vector encoding a bacterial

Indexed as

Cytosine DeaminaseFlucytosineProstatic Neoplasms, Castration-ResistantTelomeraseAdipose TissueAnimalsApoptosisCell Line, TumorCell ProliferationHumansMaleMiceMice, NudePC-3 CellsStem CellsXenograft Model Antitumor AssaysCytosine DeaminaseFlucytosineTelomeraseTERT protein, humancytosine deaminaseprostate cancerstem cells

Identifiers

PMID38791557
PMCPMC11121865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.