Evidence map›Paper›PMID 38791531›Full record

ArticleInternational journal of molecular sciences2024

Modelling the In Vivo and Ex Vivo DNA Damage Response after Internal Irradiation of Blood from Patients with Thyroid Cancer.

Sarah Schumann, Harry Scherthan, Philipp E Hartrampf, Lukas Göring, Andreas K Buck, Matthias Port, Michael Lassmann, Uta Eberlein

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Continuous βClinical and translational radiation oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah SchumannDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-4303-7068
Harry ScherthanBundeswehr Institute of Radiobiology Affiliated to the University of Ulm, 80937 Munich, Germany.
Philipp E HartrampfDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0001-5622-9849
Lukas GöringDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.
Matthias PortBundeswehr Institute of Radiobiology Affiliated to the University of Ulm, 80937 Munich, Germany.
Michael LassmannDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-2556-1977
Uta EberleinDepartment of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-2577-3195

Funding

Bundeswehr Medical Service E/U2AD/KA367/KF554EURATOM research and training programme 2014-2018 755523
6 · The paper itself

Abstract

This work reports on a model that describes patient-specific absorbed dose-dependent DNA damage response in peripheral blood mononuclear cells of thyroid cancer patients during radioiodine therapy and compares the results with the ex vivo DNA damage response in these patients. Blood samples of 18 patients (nine time points up to 168 h post-administration) were analyzed for radiation-induced γ-H2AX + 53BP1 DNA double-strand break foci (RIF). A linear one-compartment model described the absorbed dose-dependent time course of RIF (Parameters:

Indexed as

DNA Breaks, Double-StrandedDNA RepairThyroid NeoplasmsAdultAgedDNA DamageFemaleHistonesHumansIodine RadioisotopesLeukocytes, MononuclearMaleMiddle AgedModels, BiologicalTumor Suppressor p53-Binding Protein 1H2AX protein, humanHistonesIodine RadioisotopesTP53BP1 protein, humanTumor Suppressor p53-Binding Protein 153BP1DNA damageDNA damage repairdosimetrymodellingradiobiologyγ-H2AX

Identifiers

PMID38791531
PMCPMC11122196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.