Evidence map›Paper›PMID 38791514›Full record

ArticleInternational journal of molecular sciences2024

N-3 Polyunsaturated Fatty Acids Protect against Alcoholic Liver Steatosis by Activating FFA4 in Kupffer Cells.

Saeromi Kang, Jung-Min Koh, Dong-Soon Im

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Special Issue "Alcohol and Inflammation".International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saeromi KangResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Jung-Min KohDivision of Endocrinology and Metabolism, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, Republic of Korea.ORCID 0000-0002-7987-3677
Dong-Soon ImResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.ORCID 0000-0001-8054-8946

Funding

National research foundation of Korea NRF-2023R1A2C2002380, NRF-2019R1I1A1A01060819, and NRF- 2021R1I1A1A01058855
6 · The paper itself

Abstract

Supplementation with fish oil rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) effectively reduces acute and chronic alcohol-induced hepatic steatosis. We aimed to find molecular mechanisms underlying the effects of n-3 PUFAs in alcohol-induced hepatic steatosis. Because free fatty acid receptor 4 (FFA4, also known as GPR120) has been found as a receptor for n-3 PUFAs in an ethanol-induced liver steatosis model, we investigated whether n-3 PUFAs protect against liver steatosis via FFA4 using AH7614, an FFA4 antagonist, and

Indexed as

EthanolFatty Acids, Omega-3Fatty Liver, AlcoholicKupffer CellsReceptors, G-Protein-CoupledAnimalsHepatocytesMaleMiceMice, Inbred C57BLMice, KnockoutProtective AgentsSterol Regulatory Element Binding Protein 1TriglyceridesEthanolFatty Acids, Omega-3FFAR4 protein, mouseProtective AgentsReceptors, G-Protein-CoupledSterol Regulatory Element Binding Protein 1TriglyceridesCpdAFFA4GPR120hepatic steatosisKupffer cellomega-3 fatty acid

Identifiers

PMID38791514
PMCPMC11122576

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.