Evidence map›Paper›PMID 38791504›Full record

ArticleInternational journal of molecular sciences2024

Normoxic Management during Cardiopulmonary Bypass Does Not Reduce Cerebral Mitochondrial Dysfunction in Neonatal Swine.

Danielle I Aronowitz, Tracy R Geoffrion, Sarah Piel, Sarah R Morton, Jonathan Starr, Richard W Melchior, Hunter A Gaudio, Rinat Degani, Nicholas J Widmann, M Katie Weeks and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Danielle I AronowitzDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-0043-8558
Tracy R GeoffrionDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Sarah PielResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Sarah R MortonResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jonathan StarrResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Richard W MelchiorDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Hunter A GaudioResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rinat DeganiResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0001-5785-3766
Nicholas J WidmannResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
M Katie WeeksResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Nicolina R RanieriDepartment of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-6823-8328
Emilie BensonDepartment of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0001-7633-489X
Tiffany S KoResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-5113-0310
Daniel J LichtDepartment of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Marco HeftiDepartment of Pathology, University of Iowa Health Care, Iowa City, IA 52242, USA.
J William GaynorDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0001-7955-5604
Todd J KilbaughResuscitation Science Center of Emphasis, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-4959-3092
Constantine D MavroudisDivision of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Funding

Children's Hospital of Philadelphia: 00000894 Children's Hospital of Philadelphia: 00000894
6 · The paper itself

Abstract

Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic oxygen management. This study investigates whether controlled oxygenation (normoxia) during CPB reduces cortical mitochondrial dysfunction and oxidative injury. Ten neonatal swine underwent three hours of continuous CPB at 34 °C (flow > 100 mL/kg/min) via cervical cannulation targeting a partial pressure of arterial oxygen (PaO

Indexed as

Animals, NewbornCardiopulmonary BypassMitochondriaOxygenReactive Oxygen SpeciesAnimalsCerebral CortexHyperoxiaLactic AcidOxidative StressOxygen ConsumptionPyruvic AcidSwineLactic AcidOxygenPyruvic AcidReactive Oxygen Speciesanimal modelsbrain injurycardiopulmonary bypass

Identifiers

PMID38791504
PMCPMC11122014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.