Evidence map›Paper›PMID 38791502›Full record

ReviewInternational journal of molecular sciences2024

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections.

Bo Wang, Lin Du, Baiping Dong, Erwen Kou, Liangzhe Wang, Yuanjie Zhu

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Targeting Outer Membrane Vesicles ofJournal of microbiology and biotechnology · 2026
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  18. In Vitro Susceptibility of Clinical and Carrier Strains ofInternational journal of molecular sciences · 2024
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bo WangDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, China.
Lin DuDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, China.
Baiping DongDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, China.
Erwen KouDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, China.
Liangzhe WangDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, China.
Yuanjie ZhuDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, China.

Funding

National Natural Science Foundation of China 32201251Shanghai Collaborative Innovation Project XTCX-KJ-2023-44
6 · The paper itself

Abstract

Wound infection is one of the most important factors affecting wound healing, so its effective control is critical to promote the process of wound healing. However, with the increasing prevalence of multi-drug-resistant (MDR) bacterial strains, the prevention and treatment of wound infections are now more challenging, imposing heavy medical and financial burdens on patients. Furthermore, the diminishing effectiveness of conventional antimicrobials and the declining research on new antibiotics necessitate the urgent exploration of alternative treatments for wound infections. Recently, phage therapy has been revitalized as a promising strategy to address the challenges posed by bacterial infections in the era of antibiotic resistance. The use of phage therapy in treating infectious diseases has demonstrated positive results. This review provides an overview of the mechanisms, characteristics, and delivery methods of phage therapy for combating pathogenic bacteria. Then, we focus on the clinical application of various phage therapies in managing refractory wound infections, such as diabetic foot infections, as well as traumatic, surgical, and burn wound infections. Additionally, an analysis of the potential obstacles and challenges of phage therapy in clinical practice is presented, along with corresponding strategies for addressing these issues. This review serves to enhance our understanding of phage therapy and provides innovative avenues for addressing refractory infections in wound healing.

Indexed as

Phage TherapyWound InfectionAnimalsAnti-Bacterial AgentsBacterial InfectionsBacteriophagesDrug Resistance, Multiple, BacterialHumansWound HealingAnti-Bacterial Agentsalternative treatmentsantibiotic resistanceMDRphage therapywound healingwound infection

Identifiers

PMID38791502
PMCPMC11122179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.