Evidence map›Paper›PMID 38791376›Full record

ArticleInternational journal of molecular sciences2024

Modulation of Serotonin-Related Genes by Extracellular Vesicles of the Probiotic

Yenifer Olivo-Martínez, Sergio Martínez-Ruiz, Cecilia Cordero-Alday, Manel Bosch, Josefa Badia, Laura Baldoma

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Intestinal Epithelial-Protective Effects ofJournal of microbiology and biotechnology · 2026
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  3. [Research progress on the mechanism and potential applications of gut microbiota-derived extracellular vesicles in ischemic stroke].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yenifer Olivo-MartínezDepartament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-9269-3817
Sergio Martínez-RuizDepartament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-7394-3438
Cecilia Cordero-AldayDepartament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.
Manel BoschUnitat de Microscòpia Òptica Avançada, Centres Científics i Tecnològics, Universitat de Barcelona, 08028 Barcelona, Spain.
Josefa BadiaDepartament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-0768-5033
Laura BaldomaDepartament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-7678-269X

Funding

Ministerio de Ciencia, Innovación y Universidades PID2022-137192OB-I00
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory condition involving dysregulated immune responses and imbalances in the gut microbiota in genetically susceptible individuals. Current therapies for IBD often have significant side-effects and limited success, prompting the search for novel therapeutic strategies. Microbiome-based approaches aim to restore the gut microbiota balance towards anti-inflammatory and mucosa-healing profiles. Extracellular vesicles (EVs) from beneficial gut microbes are emerging as potential postbiotics. Serotonin plays a crucial role in intestinal homeostasis, and its dysregulation is associated with IBD severity. Our study investigated the impact of EVs from the probiotic Nissle 1917 (EcN) and commensal

Indexed as

Escherichia coliExtracellular VesiclesInflammationInterleukin-1betaIntestinal MucosaMicroRNAsProbioticsSerotoninCaco-2 CellsEpithelial CellsGene Expression RegulationHumansInflammatory Bowel DiseasesNod1 Signaling Adaptor ProteinOxidative StressSerotonin Plasma Membrane Transport ProteinsInterleukin-1betaMicroRNAsNOD1 protein, humanNod1 Signaling Adaptor ProteinSerotoninSerotonin Plasma Membrane Transport ProteinsTLR4 protein, humanToll-Like Receptor 4extracellular vesiclesgut microbiotainflammatory bowel disease (IBD)intestinal barrier permeabilitymiR-200amiR-24postbioticsserotonin transporter (SERT)

Identifiers

PMID38791376
PMCPMC11121267

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.