Evidence map›Paper›PMID 38791326›Full record

ArticleInternational journal of molecular sciences2024

Manganese and Vanadium Co-Exposure Induces Severe Neurotoxicity in the Olfactory System: Relevance to Metal-Induced Parkinsonism.

Hilary Afeseh Ngwa, Alejandra Bargues-Carot, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Eosinophil cationic protein-driven type 2 inflammation impairs olfactory function in a murine model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hilary Afeseh NgwaIowa Center for Advanced Neurotoxicity, Department of Biomedical Sciences, Iowa State University, Ames, IA 50010, USA.
Alejandra Bargues-CarotIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Huajun JinIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Vellareddy AnantharamIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Arthi KanthasamyIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA.
Anumantha G KanthasamyIowa Center for Advanced Neurotoxicity, Department of Biomedical Sciences, Iowa State University, Ames, IA 50010, USA.

Funding

MMT, DOPAMINERGIC DEGENERATION, AND AGINGR01ES010586 · NIEHS · IOWA STATE UNIVERSITY · PI KANTHASAMY, ANUMANTHA GOUNDER · 2000 to 2015
$4.6M
Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity.R01ES026892 · NIEHS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2016 to 2020
$2.0M
Role of Prokineticin 2 in Metal NeurotoxicityR01ES034196 · NIEHS · UNIVERSITY OF GEORGIA · PI ARTHI KANTHASAMY, Anumantha Gounder Kanthasamy · 2023 to 2026
$1.7M
NIEHS NIH HHS R01 ES010586NIEHS NIH HHS R01 ES026892NIEHS NIH HHS R01 ES034196NIH HHS ES010586NIH HHS ES026892NIH HHS ES034196United States Department of Defense W81XWH1810106
6 · The paper itself

Abstract

Chronic environmental exposure to toxic heavy metals, which often occurs as a mixture through occupational and industrial sources, has been implicated in various neurological disorders, including Parkinsonism. Vanadium pentoxide (V

Indexed as

ManganeseManganese CompoundsMice, Inbred C57BLVanadium3,4-Dihydroxyphenylacetic AcidAldehydesalpha-SynucleinAnimalsChloridesDisease Models, AnimalDopamineMaleMiceOlfactory BulbOxidative StressParkinsonian Disorders3,4-Dihydroxyphenylacetic AcidAldehydesalpha-SynucleinChloridesDopamineManganesemanganese chlorideManganese CompoundsTyrosine 3-MonooxygenaseVanadiumVanadium Compoundsvanadium pentoxidealpha-synucleinmanganesemetal mixturesneurotoxicityParkinsonismvanadium

Identifiers

PMID38791326
PMCPMC11121436

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.