Evidence map›Paper›PMID 38791316›Full record

ReviewInternational journal of molecular sciences2024

Pathogenesis of Pulmonary Manifestations in ANCA-Associated Vasculitis and Goodpasture Syndrome.

Evangelia Fouka, Fotios Drakopanagiotakis, Paschalis Steiropoulos

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. A Case Report of Granulomatosis with Polyangiitis Presenting with Chronic Conjunctivitis.Journal of education & teaching in emergency medicine · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Evangelia FoukaDepartment of Respiratory Medicine, General Hospital G. Papanikolaou, Medical School, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece.ORCID 0000-0003-4456-8987
Fotios DrakopanagiotakisDepartment of Respiratory Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-4408-291X
Paschalis SteiropoulosDepartment of Respiratory Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0001-7121-6253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary manifestations of vasculitis are associated with significant morbidity and mortality in affected individuals. They result from a complex interplay between immune dysregulation, which leads to vascular inflammation and tissue damage. This review explored the underlying pathogenesis of pulmonary involvement in vasculitis, encompassing various forms such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and anti-GBM disease. Mechanisms involving ANCA and anti-GBM autoantibodies, neutrophil activation, and neutrophil extracellular trap (NETs) formation are discussed, along with the role of the complement system in inducing pulmonary injury. Furthermore, the impact of genetic predisposition and environmental factors on disease susceptibility and severity was considered, and the current treatment options were presented. Understanding the mechanisms involved in the pathogenesis of pulmonary vasculitis is crucial for developing targeted therapies and improving clinical outcomes in affected individuals.

Indexed as

Anti-Glomerular Basement Membrane DiseaseAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisAnimalsAntibodies, Antineutrophil CytoplasmicAutoantibodiesExtracellular TrapsHumansLungLung DiseasesMicroscopic PolyangiitisAntibodies, Antineutrophil CytoplasmicAutoantibodiesANCA-associated vasculitislungpathogenesis

Identifiers

PMID38791316
PMCPMC11121030

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.