Evidence map›Paper›PMID 38791290›Full record

ArticleInternational journal of molecular sciences2024

Interaction between miR-142-3p and

Ettore Dolcetti, Alessandra Musella, Sara Balletta, Luana Gilio, Antonio Bruno, Mario Stampanoni Bassi, Gianluca Lauritano, Fabio Buttari, Diego Fresegna, Alice Tartacca and 11 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ettore DolcettiNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0002-4594-4895
Alessandra MusellaSynaptic Immunopathology Laboratory, IRCCS San Raffaele Roma, 00163 Rome, Italy.
Sara BallettaNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0001-5524-6524
Luana GilioNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0001-7132-9098
Antonio BrunoNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Mario Stampanoni BassiNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Gianluca LauritanoNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Fabio ButtariNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Diego FresegnaSynaptic Immunopathology Laboratory, IRCCS San Raffaele Roma, 00163 Rome, Italy.ORCID 0000-0002-6943-1904
Alice TartaccaPh.D. Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Fabrizio MarianiDepartment of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.
Federica PalmerioPh.D. Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Valentina RovellaDepartment of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0002-3311-486X
Rosangela FereseNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0001-8899-0309
Stefano GambardellaNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Emiliano GiardinaGenomic Medicine Laboratory, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
Annamaria FinardiClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Roberto FurlanClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0001-7376-9425
Georgia MandolesiSynaptic Immunopathology Laboratory, IRCCS San Raffaele Roma, 00163 Rome, Italy.ORCID 0000-0003-3612-6820
Diego CentonzeNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Francesca De VitoNeurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0002-6543-5756

Funding

Consiglio Nazionale delle Ricerche (CNR) ADOPT co-funded by FOE 2020 and FOE 2021 Nuovi Biomarker Diagnostici e Terapeutici delle Malattie NeurodegenerativeFondazione Italiana Sclerosi Multipla (FISM) and financed or co-financed with the '5 per mille' public funding project grant 2019/S/1Fondazione Italiana Sclerosi Multipla (FISM) and financed or co-financed with the '5 per mille' public funding project grant 2022/S/2 to DCFondazione Italiana Sclerosi Multipla (FISM) and financed or co-financed with the '5 per mille' public funding senior research fellowship 2020/BS/003Italian Ministry of Health GR-2018-12366154Italian Ministry of Health RF-2018-12366144Italian Ministry of University and Research MNESYS PE0000006 PNRRPrivate donations In memory of Veronica Tozzi
6 · The paper itself

Abstract

MiR-142-3p has recently emerged as key factor in tailoring personalized treatments for multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS) with heterogeneous pathophysiology and an unpredictable course. With its involvement in a detrimental regulatory axis with interleukin-1beta (IL1β), miR-142-3p orchestrates excitotoxic synaptic alterations that significantly impact both MS progression and therapeutic outcomes. In this study, we investigated for the first time the influence of individual genetic variability on the miR-142-3p excitotoxic effect in MS. We specifically focused on the single-nucleotide polymorphism Val66Met (rs6265) of the brain-derived neurotrophic factor (

Indexed as

Brain-Derived Neurotrophic FactorInterleukin-1betaMicroRNAsMultiple SclerosisPolymorphism, Single NucleotideAdultFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedSeverity of Illness IndexBDNF protein, humanBrain-Derived Neurotrophic FactorIL1B protein, humanInterleukin-1betaMicroRNAsMIRN142 microRNA, humanbiomarkermicroRNAneuroinflammationproinflammatory cytokinesynapsissynaptopathy

Identifiers

PMID38791290
PMCPMC11121620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.