Evidence map›Paper›PMID 38791251›Full record

ArticleInternational journal of molecular sciences2024

Mucolytic Drugs Ambroxol and Bromhexine: Transformation under Aqueous Chlorination Conditions.

Sergey A Sypalov, Ilya S Varsegov, Nikolay V Ulyanovskii, Albert T Lebedev, Dmitry S Kosyakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sergey A SypalovLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Emb. 17, 163002 Arkhangelsk, Russia.ORCID 0000-0002-2947-5099
Ilya S VarsegovLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Emb. 17, 163002 Arkhangelsk, Russia.
Nikolay V UlyanovskiiLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Emb. 17, 163002 Arkhangelsk, Russia.ORCID 0000-0003-4796-9313
Albert T LebedevLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Emb. 17, 163002 Arkhangelsk, Russia.ORCID 0000-0002-6459-9484
Dmitry S KosyakovLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Emb. 17, 163002 Arkhangelsk, Russia.ORCID 0000-0001-5223-6857

Funding

Russian Science Foundation 24-43-00153
6 · The paper itself

Abstract

Bromhexine and ambroxol are among the mucolytic drugs most widely used to treat acute and chronic respiratory diseases. Entering the municipal wastewater and undergoing transformations during disinfection with active chlorine, these compounds can produce nitrogen- and bromine-containing disinfection by-products (DBPs) that are dangerous for aquatic ecosystems. In the present study, primary and deep degradation products of ambroxol and bromhexine obtained in model aquatic chlorination experiments were studied via the combination of high-performance liquid and gas chromatography with high-resolution mass spectrometry. It was shown that at the initial stages, the reactions of cyclization, hydroxylation, chlorination, electrophilic

Indexed as

AmbroxolBromhexineExpectorantsHalogenationWater Pollutants, ChemicalChlorineWater PurificationAmbroxolBromhexineChlorineExpectorantsWater Pollutants, Chemicalambroxolbromhexinechlorinationchromatographydisinfection byproductshigh-resolution mass spectrometry

Identifiers

PMID38791251
PMCPMC11121625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.