Cardiac Left Ventricular miRNA-26a Is Downregulated in Ovariectomized Mice, Upregulated upon 17-Beta Estradiol Replacement, and Inversely Correlated with Collagen Type 1 Gene Expression.

Elishai Assayag, Irina Gurt, Einav Cohen-Kfir, Joshua Stokar, Donna R Zwas, Rivka Dresner-Pollak

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elishai AssayagDepartment of Endocrinology and Metabolism, Division of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.ORCID 0000-0003-2333-9923

Irina GurtDepartment of Endocrinology and Metabolism, Division of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.ORCID 0009-0005-2229-0488

Einav Cohen-KfirDepartment of Endocrinology and Metabolism, Division of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Joshua StokarDepartment of Endocrinology and Metabolism, Division of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.ORCID 0000-0003-4939-5800

Donna R ZwasLinda Joy Pollin Cardiovascular Wellness Center for Women, Division of Cardiology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.ORCID 0000-0003-3025-3941

Rivka Dresner-PollakDepartment of Endocrinology and Metabolism, Division of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Funding

Hadassah Medical Center N/AThis research was funded by Linda Joy Pollin Cardiovascular Wellness Center for Women, Divi-sion of Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel N/A

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) is more prevalent in post- compared to pre-menopausal women. The underlying mechanisms are not fully understood. Data in humans is confounded by age and co-morbidities. We investigated the effects of ovariectomy and estrogen replacement on the left ventricular (LV) gene expression of pro-inflammatory and pro-fibrotic factors involved in HFpEF and putative regulating miRNAs. Nine-week-old C57BL/6 female mice were subjected to ovariectomy (OVX) or SHAM operation. OVX and SHAM groups were sacrificed 1-, 6-, and 12-weeks post-surgery (T1/SHAM; T1/OVX; T6/SHAM; T6/OVX, T12/SHAM). 17β-estradiol (E

Indexed as

Collagen Type IEstradiolGene Expression RegulationHeart VentriclesMicroRNAsAnimalsCollagen Type I, alpha 1 ChainCollagen Type IIIDown-RegulationEstrogen Replacement TherapyFemaleHeart FailureInterleukin-1alphaInterleukin-6MiceMice, Inbred C57BLCOL3A1 protein, mouseCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIIEstradiolInterleukin-1alphaInterleukin-6MicroRNAsMirn26 microRNA, mouse17-β estradiolC57BL/6 female micecardiac left ventricleCol1α1Col3α1miRNA-26aovariectomy

Identifiers

PMID38791190

DOI10.3390/ijms25105153

PMCPMC11121197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.