Evidence map›Paper›PMID 38791162›Full record

ArticleInternational journal of molecular sciences2024

Serum Amyloid A3 Promoter-Luciferase Reporter Mice Are Useful for Early Drug-Induced Nephrotoxicity Detection.

Ayane Kudo, Haruka Osedo, Rahmawati Aisyah, Nao Yazawa, Tolulope Peter Saliu, Kenshu Miyata, Thanutchaporn Kumrungsee, Noriyuki Yanaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayane KudoGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.
Haruka OsedoGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.
Rahmawati AisyahGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.
Nao YazawaGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.
Tolulope Peter SaliuGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.
Kenshu MiyataGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.
Thanutchaporn KumrungseeGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.ORCID 0000-0002-6196-5186
Noriyuki YanakaGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8528, Japan.ORCID 0000-0002-9564-0822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection of drug-induced kidney injury is essential for drug development. In this study, multiple low-dose aristolochic acid (AA) and cisplatin (Cis) injections increased renal mRNA levels of inflammation, fibrosis, and renal tubule injury markers. We applied a serum amyloid A3 (Saa3) promoter-driven luciferase reporter (Saa3 promoter-luc mice) to these two tubulointerstitial nephritis models and performed

Indexed as

Aristolochic AcidsLuciferasesPromoter Regions, GeneticSerum Amyloid A ProteinAnimalsCisplatinDisease Models, AnimalGenes, ReporterKidneyKidney DiseasesLuminescent MeasurementsMaleMiceMice, Inbred C57BLaristolochic acid IAristolochic AcidsCisplatinLuciferasesSaa3 protein, mouseSerum Amyloid A Proteinaristolochic acidcisplatinin vivo imagingluciferasenephrotoxicityserum amyloid A3

Identifiers

PMID38791162
PMCPMC11120996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.