Evidence map›Paper›PMID 38791145›Full record

ArticleInternational journal of molecular sciences2024

Diagnostic and Prognostic Value of Plasma GFAP in Sporadic Creutzfeldt-Jakob Disease in the Clinical Setting of Rapidly Progressive Dementia.

Giuseppe Mario Bentivenga, Simone Baiardi, Andrea Mastrangelo, Corrado Zenesini, Angela Mammana, Marcello Rossi, Barbara Polischi, Sabina Capellari, Piero Parchi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppe Mario BentivengaDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, 40139 Bologna, Italy.
Simone BaiardiDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, 40139 Bologna, Italy.ORCID 0000-0002-7702-7856
Andrea MastrangeloDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, 40139 Bologna, Italy.
Corrado ZenesiniIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Angela MammanaIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Marcello RossiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Barbara PolischiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.
Sabina CapellariDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, 40139 Bologna, Italy.ORCID 0000-0003-1631-1439
Piero ParchiDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, 40139 Bologna, Italy.ORCID 0000-0002-9444-9524

Funding

Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

The diagnostic and prognostic value of plasma glial fibrillary acidic protein (pl-GFAP) in sporadic Creutzfeldt-Jakob disease (sCJD) has never been assessed in the clinical setting of rapidly progressive dementia (RPD). Using commercially available immunoassays, we assayed the plasma levels of GFAP, tau (pl-tau), and neurofilament light chain (pl-NfL) and the CSF total tau (t-tau), 14-3-3, NfL, phospho-tau181 (p-tau), and amyloid-beta isoforms 42 (Aβ

Indexed as

Amyloid beta-PeptidesBiomarkersCreutzfeldt-Jakob SyndromeDementiaGlial Fibrillary Acidic Proteintau Proteins14-3-3 ProteinsAgedDisease ProgressionFemaleHumansMaleMiddle AgedNeurofilament ProteinsPrognosis14-3-3 ProteinsAmyloid beta-PeptidesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsAlzheimer’s diseasebiomarkerco-pathologyCreutzfeldt–Jakob diseaseGFAPneurodegenerationneuroinflammationprion

Identifiers

PMID38791145
PMCPMC11121136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.