Evidence map›Paper›PMID 38791052›Full record

ReviewBiomedicines2024

Unlocking the Future of Periodontal Regeneration: An Interdisciplinary Approach to Tissue Engineering and Advanced Therapeutics.

Tsung-Hsi Huang, Jui-Yi Chen, Wei-Hsin Suo, Wen-Rou Shao, Chih-Ying Huang, Ming-Tse Li, Yu-Ying Li, Yuan-Hong Li, En-Lun Liang, Yu-Hsu Chen and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tsung-Hsi HuangDepartment of Orthopedic Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan.
Jui-Yi ChenSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wei-Hsin SuoSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wen-Rou ShaoSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chih-Ying HuangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Ming-Tse LiSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yu-Ying LiSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yuan-Hong LiSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
En-Lun LiangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yu-Hsu ChenDepartment of Orthopedic Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan.ORCID 0000-0001-5535-9705
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-8451-0280

Funding

Taoyuan General Hospital, Ministry of Health and Welfare PTH112021
6 · The paper itself

Abstract

Periodontal defects present a significant challenge in dentistry, necessitating innovative solutions for comprehensive regeneration. Traditional restoration methods have inherent limitations in achieving complete and functional periodontal tissue reconstruction. Tissue engineering, a multidisciplinary approach integrating cells, biomaterials, and bioactive factors, holds tremendous promise in addressing this challenge. Central to tissue engineering strategies are scaffolds, pivotal in supporting cell behavior and orchestrating tissue regeneration. Natural and synthetic materials have been extensively explored, each offering unique advantages in terms of biocompatibility and tunable properties. The integration of growth factors and stem cells further amplifies the regenerative potential, contributing to enhanced tissue healing and functional restoration. Despite significant progress, challenges persist. Achieving the seamless integration of regenerated tissues, establishing proper vascularization, and developing biomimetic scaffolds that faithfully replicate the natural periodontal environment are ongoing research endeavors. Collaborative efforts across diverse scientific disciplines are essential to overcoming these hurdles. This comprehensive review underscores the critical need for continued research and development in tissue engineering strategies for periodontal regeneration. By addressing current challenges and fostering interdisciplinary collaborations, we can unlock the full regenerative potential, paving the way for transformative advancements in periodontal care. This research not only enhances our understanding of periodontal tissues but also offers innovative approaches that can revolutionize dental therapies, improving patient outcomes and reshaping the future of periodontal treatments.

Indexed as

3D printingenamelgene therapyperiodontal ligamentregenerationstem cell

Identifiers

PMID38791052
PMCPMC11118048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.