Evidence map›Paper›PMID 38791026›Full record

ArticleBiomedicines2024

Efficacy of Engraftment and Safety of Human Umbilical Di-Chimeric Cell (HUDC) Therapy after Systemic Intraosseous Administration in an Experimental Model.

Maria Siemionow, Lucile Chambily, Sonia Brodowska

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria SiemionowDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-6372-6122
Lucile ChambilyDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0009-0008-3377-3284
Sonia BrodowskaDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-0546-0060

Funding

Armed Forces Institute for Regenerative Medicine, AFIRM II W81XWH-13-2-0053U.S. Army Medical Research Acquisition Activity 21702-5014
6 · The paper itself

Abstract

Cell-based therapies hold promise for novel therapeutic strategies in regenerative medicine. We previously characterized in vitro human umbilical di-chimeric cells (HUDCs) created via the ex vivo fusion of human umbilical cord blood (UCB) cells derived from two unrelated donors. In this in vivo study, we assessed HUDC safety and biodistribution in the NOD SCID mouse model at 90 days following the systemic intraosseous administration of HUDCs. Twelve NOD SCID mice (

Indexed as

biodistributioncell-based therapydonor-specific chimerismhuman umbilical di-chimeric cell (HUDC) therapyregenerative medicinesafetysystemic intraosseous administrationtolerance inductiontransplantationumbilical cord blood (UCB) cells

Identifiers

PMID38791026
PMCPMC11117770

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.