Evidence map›Paper›PMID 38791000›Full record

ArticleBiomedicines2024

Enrichment of Bioactive Lipids in Urinary Extracellular Vesicles and Evidence of Apoptosis in Kidneys of Hypertensive Diabetic Cathepsin B Knockout Mice after Streptozotocin Treatment.

Whitney C Schramm, Niharika Bala, Tanmay Arekar, Zeeshan Malik, Kevin M Chacko, Russell L Lewis, Nancy D Denslow, Yogesh Scindia, Abdel A Alli

Registry-linked trialAbstract read
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In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07056283 (The Study of Urinary Biomarkers in Patients With Hypomagnesemia), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07056283 recruitingnot on this mapstarted 2025, after this paper: background citation

The Study of Urinary Biomarkers in Patients With Hypomagnesemia

TypeobservationalSponsorUniversity of FloridaRan2025 to 2027Enrolled15ConditionsHypomagnesemia
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Whitney C SchrammDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Niharika BalaDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-0658-9923
Tanmay ArekarDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Zeeshan MalikDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kevin M ChackoDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Russell L LewisDepartment of Physiological Sciences, Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32608, USA.
Nancy D DenslowDepartment of Physiological Sciences, Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32608, USA.
Yogesh ScindiaDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Abdel A AlliDepartment of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-4381-1172

Funding

Targeting ferroptosis in renal tubular epithelial cells to improve outcomes of lupus nephritisR01DK136011 · NIDDK · UNIVERSITY OF FLORIDA · PI Laurence Morel, Yogesh Scindia · 2023 to 2026
$1.8M
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidneyR01DK123078 · NIDDK · UNIVERSITY OF FLORIDA · PI ALLI, ABDEL AYUBE · 2020 to 2024
$1.7M
Applied Biosystems SCIEX Q-TRAP 6500 LC/MS/MS Mass SpectrometerS10OD018141 · OD · UNIVERSITY OF FLORIDA · PI DENSLOW, NANCY D · 2015 to 2015
$584k
NIDDK NIH HHS R01 DK123078NIDDK NIH HHS R01 DK136011NIH HHS 1S10OD018141NIH HHS DK123078NIH HHS DK136011NIH HHS S10 OD018141
6 · The paper itself

Abstract

Cathepsin B (CtsB) is a ubiquitously expressed cysteine protease that plays important roles in health and disease. Urinary extracellular vesicles (uEVs) are released from cells associated with urinary organs. The antibiotic streptozotocin (STZ) is known to induce pancreatic islet beta cell destruction, diabetic nephropathy, and hypertension. We hypothesized that streptozotocin-induced diabetic kidney disease and hypertension result in the release of bioactive lipids from kidney cells that induce oxidative stress and renal cell death. Lipidomics was performed on uEVs isolated from CtsB knockout mice treated with or without STZ, and their kidneys were used to investigate changes in proteins associated with cell death. Lysophosphatidylethanolamine (LPE) (18:1), lysophosphatidylserine (LPS) (22:6), and lysophosphatidylglycerol (LPG) (22:5) were among the bioactive lipids enriched in uEVs from CtsB knockout mice treated with STZ compared to untreated CtsB mice (

Indexed as

cathepsin Bextracellular vesiclesferroptosiskidneylipidsstreptozotocin

Identifiers

PMID38791000
PMCPMC11117475

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.