Evidence map›Paper›PMID 38790952›Full record

ArticleBiomedicines2024

Characterization of a Clinically and Biologically Defined Subgroup of Patients with Autism Spectrum Disorder and Identification of a Tailored Combination Treatment.

Laura Pérez-Cano, Luigi Boccuto, Francesco Sirci, Jose Manuel Hidalgo, Samuel Valentini, Mattia Bosio, Xavier Liogier D'Ardhuy, Cindy Skinner, Lauren Cascio, Sujata Srikanth and 7 more

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Shared and distinct phenotypic profiles among neurodevelopmental disorder genes.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Laura Pérez-CanoDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.ORCID 0000-0003-1912-2027
Luigi BoccutoJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.ORCID 0000-0003-2017-4270
Francesco SirciDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.
Jose Manuel HidalgoDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.ORCID 0000-0002-3787-5236
Samuel ValentiniDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.
Mattia BosioDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.
Xavier Liogier D'ArdhuyDrug Development Unit (DDU), STALICLA SA, Avenue de Sécheron 15, 1202 Geneva, Switzerland.
Cindy SkinnerJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.ORCID 0000-0002-7841-8277
Lauren CascioJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.ORCID 0000-0001-6086-4140
Sujata SrikanthJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.
Kelly JonesJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.
Caroline B BuchananJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.
Steven A SkinnerJC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29649, USA.
Baltazar Gomez-MancillaDrug Development Unit (DDU), STALICLA SA, Avenue de Sécheron 15, 1202 Geneva, Switzerland.
Jean-Marc HyvelinDrug Development Unit (DDU), STALICLA SA, Avenue de Sécheron 15, 1202 Geneva, Switzerland.
Emre GuneyDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.ORCID 0000-0002-3466-6535
Lynn DurhamDiscovery and Data Science (DDS) Unit, STALICLA SL, Moll de Barcelona, s/n, Edif Este, 08039 Barcelona, Spain.

Funding

STALICLA S.A. NA
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders (NDDs) with a high unmet medical need. The diagnosis of ASD is currently based on behavior criteria, which overlooks the diversity of genetic, neurophysiological, and clinical manifestations. Failure to acknowledge such heterogeneity has hindered the development of efficient drug treatments for ASD and other NDDs. DEPI

Indexed as

ASD Phenotype 1cAMPDEPImetabolic and transcriptomic alterationsNF-κBNRF2precision medicineSTP1 tailored treatmentWarburg effect

Identifiers

PMID38790952
PMCPMC11117897

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.