Evidence map›Paper›PMID 38790926›Full record

ArticleBiomedicines2024

Exhaled Nitric Oxide Reflects the Immune Reactions of the Airways in Early Rheumatoid Arthritis.

Tomas Weitoft, Johan Rönnelid, Anders Lind, Charlotte de Vries, Anders Larsson, Barbara Potempa, Jan Potempa, Alf Kastbom, Klara Martinsson, Karin Lundberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomas WeitoftCentre for Research and Development, Uppsala University, Region Gävleborg, 801 88 Gävle, Sweden.ORCID 0000-0002-8371-7116
Johan RönnelidDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0003-1186-3226
Anders LindCentre for Research and Development, Uppsala University, Region Gävleborg, 801 88 Gävle, Sweden.
Charlotte de VriesRheumatology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Solna, Sweden.ORCID 0000-0003-4513-4128
Anders LarssonClinical Chemistry, Department of Medical Science, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0003-3161-0402
Barbara PotempaDepartment of Oral Immunity and Infectious Diseases, School of Dentistry, University of Louisville, 501 S. Preston St., Louisville, KY 40202, USA.
Jan PotempaDepartment of Oral Immunity and Infectious Diseases, School of Dentistry, University of Louisville, 501 S. Preston St., Louisville, KY 40202, USA.ORCID 0000-0002-3600-7461
Alf KastbomDepartment of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0001-7187-1477
Klara MartinssonDepartment of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0003-4492-9172
Karin LundbergRheumatology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Solna, Sweden.ORCID 0000-0001-7625-964X
Marieann HögmanDepartment of Medical Science, Respiratory, Allergy and Sleep Research, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0002-6392-6092

Funding

Bacterial peptidylarginine deiminase, a link between gums and joint diseaseR01DE022597 · NIDCR · UNIVERSITY OF LOUISVILLE · PI POTEMPA, JAN S · 2013 to 2023
$3.7M
King Gustaf V:s 80-year Foundation FAI-2021-0771NIDCR NIH HHS R01 DE022597Swedish Rheumatism Association R-969194
6 · The paper itself

Abstract

Patients with rheumatoid arthritis (RA) have altered levels of exhaled nitric oxide (NO) compared with healthy controls. Here, we investigated whether the clinical features of and immunological factors in RA pathogenesis could be linked to the NO lung dynamics in early disease. A total of 44 patients with early RA and anti-citrullinated peptide antibodies (ACPAs), specified as cyclic citrullinated peptide 2 (CCP2), were included. Their exhaled NO levels were measured, and the alveolar concentration, the airway compartment diffusing capacity and the airway wall concentration of NO were estimated using the Högman-Meriläinen algorithm. The disease activity was measured using the Disease Activity Score for 28 joints. Serum samples were analysed for anti-CCP2, rheumatoid factor, free secretory component, secretory component containing ACPAs, antibodies against

Indexed as

ACPAexhaled nitric oxidefree secretory componentlungpathogenesisrheumatoid arthritisrheumatoid factor

Identifiers

PMID38790926
PMCPMC11118928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.