Evidence map›Paper›PMID 38790651›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Use of Optical Redox Imaging to Quantify Alveolar Macrophage Redox State in Infants: Proof of Concept Experiments in a Murine Model and Human Tracheal Aspirates Samples.

He N Xu, Diego Gonzalves, Jonathan H Hoffman, Joseph A Baur, Lin Z Li, Erik A Jensen

Erratum issuedAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Investigating Cellular Magnetic Bioeffects Using Two-Channel, Two-Photon Autofluorescence Lifetime Microscopy.IEEE transactions on molecular, biological, and multi-scale communications · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

He N XuBritton Chance Laboratory of Redox Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5127-2629
Diego GonzalvesDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jonathan H HoffmanBritton Chance Laboratory of Redox Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joseph A BaurDepartment of Physiology, and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lin Z LiBritton Chance Laboratory of Redox Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9447-7982
Erik A JensenDepartment of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1M
Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failureR01HL165792 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2022 to 2025
$2.7M
Label-Free Optical Redox Imaging for Pretreatment Prognosis of Early-Stage Triple Negative Breast CancerR01CA277037 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LIN Z LI · 2023 to 2026
$2.6M
Microbiome of the Airway and the Risk for Bronchopulmonary Dysplasia in the Lungs of Extreme Preterms: The MARBLE StudyK23HL136843 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI JENSEN, ERIK ALLEN · 2018 to 2022
$819k
National Heart Lung and Blood Institute K23HL136843NCATS NIH HHS UL1 TR001878NCI NIH HHS R01 CA277037NHLBI NIH HHS K23 HL136843NHLBI NIH HHS R01 HL165792the National Center for Advancing Translational Sciences of the National Institutes of Health UL1TR001878
6 · The paper itself

Abstract

Emerging data indicate that lung macrophages (LM) may provide a novel biomarker to classify disease endotypes in bronchopulmonary dysplasia (BPD), a form of infant chronic lung disease, and that augmentation of the LM phenotype may be a potential therapeutic target. To contribute to this area of research, we first used Optical Redox Imaging (ORI) to characterize the responses to H

Indexed as

alveolar/lung macrophagesautofluorescence fluorescence imagingbronchopulmonary dysplasia (BPD)gestational agemean airway pressuremitochondrial redox statemitochondrial ROSnicotinamide adenine dinucleotide (NAD+ and NADH)preterm infants

Identifiers

PMID38790651
PMCPMC11117937

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.