ArticleAntioxidants (Basel, Switzerland)2024
Biochemical and Molecular Insights into Variation in Sesame Seed Antioxidant Capability as Revealed by Metabolomics and Transcriptomics Analysis.
Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Origin-specific metabolomic profiling and network pharmacology propose potential multi-target antioxidant mechanisms of black sesame seeds.Food chemistry: X · 2026Article
- Evaluation of Sesame (Plants (Basel, Switzerland) · 2026Article
- Organ-Specific Metabolite Profiling ofACS omega · 2026Article
- Integrating Meta-QTL Analysis and Genome-Wide Association Mapping in Ethiopian Sesame (Plants (Basel, Switzerland) · 2026Article
- Metabolomic and biochemical insights into bioactive compounds and antioxidant properties of black oilseed testa and peeled seeds.Current research in food science · 2025Article
- Lignan Content and Antioxidant Capacity of Eight Sesame Varieties Cultivated in Korea.Preventive nutrition and food science · 2024Article
- Comprehensive Secondary Metabolite Profiling and Antioxidant Activity of Aqueous and Ethanol Extracts ofMetabolites · 2024Article
- Evaluation of Agronomic Traits, Total Phenolic Content, and Antioxidant Properties of Sesame Seeds of Different Colors and Origin.Foods (Basel, Switzerland) · 2024Article
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10 authors.
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Abstract
Sesame seeds are important resources for relieving oxidation stress-related diseases. Although a significant variation in seeds' antioxidant capability is observed, the underlying biochemical and molecular basis remains elusive. Thus, this study aimed to reveal major seed components and key molecular mechanisms that drive the variability of seeds' antioxidant activity (AOA) using a panel of 400 sesame accessions. The seeds' AOA, total flavonoid, and phenolic contents varied from 2.03 to 78.5%, 0.072 to 3.104 mg CAE/g, and 2.717 to 21.98 mg GAE/g, respectively. Analyses revealed that flavonoids and phenolic acids are the main contributors to seeds' AOA variation, irrespective of seed coat color. LC-MS-based polyphenol profiling of high (HA) and low (LA) antioxidant seeds uncovered 320 differentially accumulated phenolic compounds (DAPs), including 311 up-regulated in HA seeds. Tricin, persicoside, 5,7,4',5'-tetrahydro-3',6-dimethoxyflavone, 8-methoxyapigenin, and 6,7,8-tetrahydroxy-5-methoxyflavone were the top five up-regulated in HA. Comparative transcriptome analysis at three seed developmental stages identified 627~2357 DEGs and unveiled that differential regulation of flavonoid biosynthesis, phenylpropanoid biosynthesis, and stilbene biosynthesis were the key underlying mechanisms of seed antioxidant capacity variation. Major differentially regulated phenylpropanoid structural genes and transcription factors were identified.
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