Evidence map›Paper›PMID 38790596›Full record

ArticleChildren (Basel, Switzerland)2024

Lower Urinary Tract Dysfunction in Pediatric Patients with Multiple Sclerosis: Diagnostic and Management Concerns.

Maria Laura Sollini, Chiara Pellegrino, Giulia Barone, Maria Luisa Capitanucci, Antonio Maria Zaccara, Leonardo Crescentini, Enrico Castelli, Gessica Della Bella, Federico Scorletti, Laura Papetti and 4 more

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Laura SolliniDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Chiara PellegrinoDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-9813-6288
Giulia BaroneDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Maria Luisa CapitanucciDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Antonio Maria ZaccaraDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Leonardo CrescentiniDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Enrico CastelliNeurorehabilitation Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0003-1685-8936
Gessica Della BellaNeurorehabilitation and Adapted Physical Activity Day Hospital, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Federico ScorlettiNeonatal Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Laura PapettiDevelopmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-3336-9205
Gabriele MonteDevelopmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Michela Ada Noris FerilliDevelopmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Massimiliano ValerianiDevelopmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-6602-103X
Giovanni MosielloDivision of Neuro-Urology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-9626-9519

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) is increasing in the pediatric population and, as in adults, symptoms vary among patients. In children the first manifestations can sometimes overlap with acute neurological symptoms. Urological symptoms have not been much studied in childhood. We shared our experience with MS urological manifestation in children.

methodsThis article is a retrospective evaluation of all children with MS, according to the Krupp criteria, who also present with urological symptoms. We collected demographic and clinical history, the MR localization of demyelinating lesions, urological symptoms, and exams.

resultsWe report on six MS pediatric cases with urological manifestation. Urinary symptoms, characterized by urinary incontinence in five patients and urinary retention in one patient, appeared in a different time frame from MS diagnosis. Urodynamic exams showed both overactive and underactive bladder patterns. Treatment was defined according to lower urinary tract dysfunction, using clean intermittent catheterization, oxybutynin, and intradetrusor Onabotulinum Toxin-A injection. A low acceptance rate of invasive evaluation and urological management was observed.

conclusionsThe MS diagnosis was traumatic for all our patients. We believe it is important to address urological care in young people from the time of diagnosis for prompt management; it could be useful to include a pediatric urologist in multidisciplinary teams.

Indexed as

LUTDLUTSmultiple sclerosisneurogenic bladderneurogenic bowelpediatric

Identifiers

PMID38790596
PMCPMC11119741

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.