Evidence map›Paper›PMID 38790522›Full record

ArticleChildren (Basel, Switzerland)2024

Direct Umbilical Vein Injection of Epinephrine with Cut-Cord Milking in an Ovine Model of Neonatal Resuscitation.

Payam Vali, Peggy Chen, Evan Giusto, Amy Lesneski, Morgan E Hardie, Heather K Knych, Deepika Sankaran, Ziad Alhassen, Houssam M Joudi, Satyan Lakshminrusimha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Payam ValiDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA.
Peggy ChenDivision of Neonatology, Miller Children's & Women's Hospital Long Beach, Long Beach, CA 90806, USA.
Evan GiustoDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-0364-0057
Amy LesneskiDepartment of Stem Cell Research, University of California Davis, Sacramento, CA 95817, USA.
Morgan E HardieSchool of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Heather K KnychK.L. Maddy Equine Analytical Pharmacology Laboratory, Department of Veterinary Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Deepika SankaranDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-6704-6949
Ziad AlhassenDivision of Neonatology, Children's Hospital of Orange County, Orange, CA 92868, USA.
Houssam M JoudiDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA.
Satyan LakshminrusimhaDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-6098-2155

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
Neonatal Hypovolemic Cardiac Arrest: Role of Early Rapid Volume ResuscitationR03HD109443 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANKARAN, DEEPIKA · 2023 to 2023
$160k
Clinical Translational Science Center UC Davis UL1TR001860National Institutes of Health Clinical Center HD072929 09NICHD NIH HHS R01 HD072929NICHD NIH HHS R03 HD109443
6 · The paper itself

Abstract

backgroundAn umbilical venous catheter (UVC) is the preferred route of epinephrine administration during neonatal resuscitation but requires specialized equipment, expertise, and time. HYPOTHESIS: Direct injection of epinephrine into the umbilical vein (UV) followed by milking a ~20 cm segment of cut umbilical cord to flush the epinephrine (DUV + UCM) will lead to a quicker administration and earlier return of spontaneous circulation (ROSC) compared with epinephrine given through a UVC.

designEighteen near-term asphyxiated lambs were randomized to receive a low-UVC or DUV + UCM of epinephrine at 0.02 or 0.03 mg/kg doses. OUTCOME MEASURES: A total of 16/18 lambs achieved ROSC with a similar mean (±SEM) time to ROSC [DUV + UCM vs. low-UVC (4.67 ± 0.67 vs. 3.99 ± 0.58 min);

conclusionsDUV + UCM resulted in a ROSC success of 78% following the first epinephrine dose and showed similar epinephrine concentrations to UVC. Clinical studies evaluating DUV + UCM as an alternate route for epinephrine while intravenous access is being established are warranted.

Indexed as

chest compressionsdelivery roomepinephrineumbilical cord milking

Identifiers

PMID38790522
PMCPMC11120376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.